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Literature summary for 7.2.2.10 extracted from

  • Carafoli, E.; Zurini, M.
    The Ca2+-pumping ATPase of plasma membranes. Purification, reconstitution and properties (1982), Biochim. Biophys. Acta, 683, 279-301.
    View publication on PubMed
Search for more literature for 7.2.2.10

Activating Compound

Activating Compound Comment Organism Structure
Calmodulin shifts the Ca2+-ATPase to the high-affinity form Homo sapiens
additional information activation by controlled proteolysis Homo sapiens
phosphatidylserine can replace calmodulin in shifting the enzyme to the high-affinity form Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4,4'-diisothiocyano-2,2'-stilbenedisulfonic acid
-
 Homo sapiens
N-4-(azido-2-nitrophenyl)-2-aminoethylsulfonate
-
 Homo sapiens
vanadate
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.000013
-
 Ca2+ enzyme from liver Homo sapiens
0.000021
-
 ATP enzyme from liver Homo sapiens
0.000037
-
 UTP enzyme from liver Homo sapiens
0.0005
-
 Ca2+ phosphatidylserine environment with or without calmodulin, enzyme from erythrocytes Homo sapiens
0.02
-
 Ca2+ phosphatidylcholine environment with or without calmodulin, enzyme from erythrocytes Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Homo sapiens 16020
-
plasma membrane
-
 Homo sapiens 5886
-
sarcoplasmic reticulum
-
 Homo sapiens 16529
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
138000
-
 x * 138000, enzyme may exist in both the monomeric and dimeric enzyme form, SDS-PAGE Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
no glycoprotein
-
 Homo sapiens
side-chain modification contains about 7 mol phosphate per mol of protein Homo sapiens

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Ca2+/out
-
 Homo sapiens ADP + phosphate + Ca2+/in
-
 ?
UTP + H2O + Ca2+/in
-
 Homo sapiens UDP + phosphate + Ca2+/out
-
 ?

Subunits

Subunits Comment Organism
? x * 138000, enzyme may exist in both the monomeric and dimeric enzyme form, SDS-PAGE Homo sapiens