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Literature summary for 7.2.1.1 extracted from

  • Minato, Y.; Fassio, S.; Reddekopp, R.; Häse, C.
    Inhibition of the sodium-translocating NADH-ubiquinone oxidoreductase [Na+-NQR] decreases cholera toxin production in Vibrio cholerae O1 at the late exponential growth phase (2014), Microb. Pathog., 66, 36-39 .
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Inhibitors

Inhibitors Comment Organism Structure
2-n-heptyl-4-hydroxyquinoline N-oxide
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 Vibrio cholerae O1

Organism

Organism UniProt Comment Textmining
Vibrio cholerae O1
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-
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Vibrio cholerae O1 ATCC 39541
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-
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General Information

General Information Comment Organism
physiological function presence of Na+-NQR affects central regulatory protein ToxT expression only at the early-log growth phase, whereas lack of Na+-NQR decreases cholera toxin production after the mid-log growth phase. Decreased cholera toxin production is independent of ToxT and CtxB transcription but dependent on electron transport chain activity. Inhibition of Na+-NQR and succinate dehydrogenase strongly inhibits cholera toxin production in both classical and El Tor biotype strains of Vibrio cholerae Vibrio cholerae O1