BRENDA - Enzyme Database
show all sequences of 7.2.1.1

Primary steps of the Na+-translocating NADH:ubiquinone oxidoreductase catalytic cycle resolved by the ultrafast freeze-quench approach

Bogachev, A.V.; Belevich, N.P.; Bertsova, Y.V.; Verkhovsky, M.I.; J. Biol. Chem. 284, 5533-5538 (2009)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
NAD+
competitive inhibitor
Vibrio harveyi
Localization
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Vibrio harveyi
16020
-
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NADH + H+ + ubiquinone + n Na+/in
Vibrio harveyi
Na+-NQR reduction is not limited by the rate of NADH binding
NAD+ + ubiquinol + n Na+/out
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Vibrio harveyi
-
-
-
Purification (Commentary)
Commentary
Organism
-
Vibrio harveyi
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NADH + H+ + ubiquinone + n Na+/in
Na+-NQR reduction is not limited by the rate of NADH binding
712407
Vibrio harveyi
NAD+ + ubiquinol + n Na+/out
-
-
-
?
Cofactor
Cofactor
Commentary
Organism
Structure
FAD
-
Vibrio harveyi
FMN
two covalently bound FMNs
Vibrio harveyi
NADH
-
Vibrio harveyi
riboflavin
-
Vibrio harveyi
ubiquinone-8
-
Vibrio harveyi
[2Fe-2S]-center
-
Vibrio harveyi
Ki Value [mM]
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
11
-
NAD+
at 30C, 100 mM KCl, 20 mM HEPES/Tris (pH 7.5)
Vibrio harveyi
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
FAD
-
Vibrio harveyi
FMN
two covalently bound FMNs
Vibrio harveyi
NADH
-
Vibrio harveyi
riboflavin
-
Vibrio harveyi
ubiquinone-8
-
Vibrio harveyi
[2Fe-2S]-center
-
Vibrio harveyi
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
NAD+
competitive inhibitor
Vibrio harveyi
Ki Value [mM] (protein specific)
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
11
-
NAD+
at 30C, 100 mM KCl, 20 mM HEPES/Tris (pH 7.5)
Vibrio harveyi
Localization (protein specific)
Localization
Commentary
Organism
GeneOntology No.
Textmining
membrane
-
Vibrio harveyi
16020
-
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
NADH + H+ + ubiquinone + n Na+/in
Vibrio harveyi
Na+-NQR reduction is not limited by the rate of NADH binding
NAD+ + ubiquinol + n Na+/out
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Vibrio harveyi
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
NADH + H+ + ubiquinone + n Na+/in
Na+-NQR reduction is not limited by the rate of NADH binding
712407
Vibrio harveyi
NAD+ + ubiquinol + n Na+/out
-
-
-
?
General Information
General Information
Commentary
Organism
physiological function
Na+-NQR is a component of respiratory chain and generates a redox-driven transmembrane electrochemical Na+ potential
Vibrio harveyi
General Information (protein specific)
General Information
Commentary
Organism
physiological function
Na+-NQR is a component of respiratory chain and generates a redox-driven transmembrane electrochemical Na+ potential
Vibrio harveyi
Other publictions for EC 7.2.1.1
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [C]
Temperature Range [C]
Temperature Stability [C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [C] (protein specific)
Temperature Range [C] (protein specific)
Temperature Stability [C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
742030
Toulouse
Strong pH dependence of coupl ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39315
Biol. Chem.
398
251-260
2017
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2
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742911
Ito
-
Identification of the binding ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39315
J. Biol. Chem.
292
7727-7742
2017
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1
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5
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5
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2
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2
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26
-
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1
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5
-
26
5
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-
2
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741981
Belevich
Identification of the couplin ...
Vibrio harveyi
Biochim. Biophys. Acta
1857
141-149
2016
1
-
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-
-
-
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1
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4
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1
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1
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-
741985
Vorburger
Role of the Na+-translocating ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39541
Biochim. Biophys. Acta
1857
473-482
2016
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4
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1
1
-
-
-
742791
Muras
The Na+-translocating NADHqui ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39315
J. Bacteriol.
198
2307-2317
2016
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-
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1
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7
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1
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1
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1
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1
1
-
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-
732678
Borshchevskiy
Structural and functional inve ...
Vibrio harveyi, Vibrio harveyi CAIM 1792
PLoS ONE
10
e0118548
2015
-
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-
1
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4
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1
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1
1
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742029
Steuber
The structure of Na+-transloc ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39315
Biol. Chem.
396
1015-1030
2015
-
-
-
1
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-
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5
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2
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1
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-
-
2
-
-
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-
-
-
-
-
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-
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-
-
732791
Minato
Roles of the sodium-translocat ...
Vibrio cholerae
PLoS ONE
9
e97083
2014
-
-
-
-
-
-
-
-
-
-
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4
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1
1
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-
-
741533
Vohl
-
Crystallization and prelimina ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39541
Acta Crystallogr. Sect. F
70
987-992
2014
-
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1
1
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2
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1
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741955
Bertsova
Localization-controlled speci ...
Klebsiella pneumoniae
Biochim. Biophys. Acta
1837
1122-1129
2014
-
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-
-
-
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5
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1
1
-
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-
742860
Strickland
The conformational changes in ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39541
J. Biol. Chem.
289
23723-23733
2014
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1
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2
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1
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3
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2
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743239
Minato
-
Inhibition of the sodium-tran ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39541
Microb. Pathog.
66
36-39
2014
-
-
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1
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2
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1
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1
1
-
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-
743346
Steuber
Structure of the V. cholerae ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39315
Nature
516
62-67
2014
-
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1
1
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8
-
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1
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1
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725538
Nedielkov
NMR reveals double occupancy o ...
Vibrio cholerae
J. Biol. Chem.
288
30597-30606
2013
-
-
1
-
-
-
3
3
3
1
-
1
-
3
-
-
1
-
-
-
-
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3
1
1
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1
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4
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1
4
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3
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3
3
1
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1
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1
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3
1
1
-
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-
1
-
-
-
-
2
2
-
-
-
725539
Shea
Aspartic acid 397 in subunit B ...
Vibrio cholerae, Vibrio cholerae ATCC 39541
J. Biol. Chem.
288
31241-31249
2013
-
-
1
-
7
-
1
12
1
3
-
1
-
8
-
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1
-
-
-
-
-
6
1
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-
-
56
1
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4
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1
4
-
14
-
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1
-
12
1
3
-
1
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1
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6
1
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56
1
-
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-
-
2
2
-
-
-
741884
Neehaul
-
Infrared spectroscopic eviden ...
Vibrio cholerae O1, Vibrio cholerae O1 ATCC 39541
Biochemistry
52
3085-3093
2013
-
-
-
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1
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1
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3
-
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3
-
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1
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3
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742842
Bertsova
Alternative pyrimidine biosyn ...
Klebsiella pneumoniae 204, Klebsiella pneumoniae, Vibrio harveyi, Vibrio harveyi R3
J. Biol. Chem.
288
14276-14286
2013
-
-
2
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2
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4
-
9
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4
2
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12
-
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2
12
-
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2
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4
-
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4
2
-
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3
3
-
-
-
725481
Juarez
The role of glycine residues 1 ...
Vibrio cholerae, Vibrio cholerae ATCC 39541
J. Biol. Chem.
287
25678-25685
2012
-
-
-
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5
-
1
11
-
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1
-
8
-
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-
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4
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10
1
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4
4
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4
-
10
-
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2
7
11
-
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-
1
-
-
-
-
-
-
-
-
4
-
-
-
-
10
1
-
-
-
-
3
3
-
1
1
724251
Fadeeva
Cys377 residue in NqrF subunit ...
Vibrio harveyi
Biochemistry (Moscow)
76
186-195
2011
-
-
1
-
2
-
8
2
1
-
-
1
-
4
-
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-
-
-
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-
3
1
1
-
-
-
1
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4
-
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1
4
-
2
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8
-
2
1
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1
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-
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-
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-
3
1
1
-
-
-
1
-
-
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-
1
1
-
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-
725433
Juarez
The role and specificity of th ...
Vibrio cholerae
J. Biol. Chem.
286
26383-26390
2011
-
-
-
-
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1
1
3
-
1
-
3
-
-
-
-
1
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3
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-
-
-
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-
4
-
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4
-
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1
1
3
-
1
-
-
-
-
1
-
-
-
3
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
725448
Casutt
Localization of ubiquinone-8 i ...
Vibrio cholerae
J. Biol. Chem.
286
40075-40082
2011
-
-
1
-
-
-
1
-
1
1
1
1
-
4
-
-
1
-
1
-
-
-
3
3
1
-
-
-
1
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-
3
-
-
-
-
-
1
3
-
-
-
-
1
-
-
1
1
1
1
-
-
-
1
1
-
-
-
3
3
1
-
-
-
1
-
-
-
-
1
1
-
-
-
710746
Casutt
Crystallization of the Na+-tra ...
Vibrio cholerae
Acta Crystallogr. Sect. F
66
1677-1679
2010
-
-
1
1
-
-
-
-
3
-
-
1
-
3
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
6
-
-
-
-
-
1
6
1
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1
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1
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1
1
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711293
Verkhovsky
Sodium-translocating NADH:quin ...
Azotobacter vinelandii, Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis, Porphyromonas gingivalis, Pseudomonas aeruginosa, Vibrio alginolyticus, Vibrio cholerae, Vibrio harveyi, Yersinia pestis
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66
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66
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87
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11
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55
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1
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Energy transducing redox steps ...
Vibrio cholerae
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1
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5
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5
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5
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1
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-
1
-
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-
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Localization and function of t ...
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1
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3
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1
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4
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1
4
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1
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1
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5
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1
1
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1
1
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Redox properties of the prosth ...
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1
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3
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3
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1
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1
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Redox properties of the prosth ...
Vibrio harveyi
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3
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3
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1
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Acid residues in the transmemb ...
Vibrio cholerae
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2
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6
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1
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3
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7
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3
2
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3
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2
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6
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The electron transfer pathway ...
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3
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4
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2
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4
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5
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1
-
1
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-
1
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3
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-
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700061
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The Na+-translocating NADH:ubi ...
Azotobacter vinelandii, Azotobacter vinelandii GG4
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2
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1
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1
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2
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-
2
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Primary steps of the Na+-trans ...
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1
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6
1
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-
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6
-
-
-
-
1
1
-
1
-
-
1
-
-
-
1
-
-
-
-
1
-
-
-
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-
-
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1
1
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696157
Fadeeva
Site-directed mutagenesis of c ...
Vibrio cholerae
Biochemistry (Moscow)
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4
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1
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2
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4
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2
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-
-
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2
-
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-
-
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696386
Tao
Oxidant-induced formation of a ...
Vibrio cholerae
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2008
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1
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1
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-
-
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4
2
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-
-
-
1
-
-
2
-
-
-
-
-
1
2
-
-
-
-
1
-
-
-
-
5
2
-
-
-
1
-
-
-
-
4
2
-
-
-
-
1
-
-
-
-
-
-
-
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697973
Fadeeva
Catalytic properties of Na+-tr ...
Azotobacter vinelandii, Klebsiella pneumoniae, Vibrio harveyi
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279
116-123
2008
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3
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5
-
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-
-
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3
-
-
3
-
-
-
3
-
-
-
3
12
-
3
-
-
-
2
-
-
-
3
-
-
-
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5
-
-
-
-
-
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698842
Juarez
Riboflavin is an active redox ...
Vibrio cholerae
J. Biol. Chem.
283
33162-33167
2008
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-
-
-
2
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-
-
-
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-
-
-
-
-
-
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-
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-
1
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-
1
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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699385
Tao
The Na+-translocating NADH:qui ...
Vibrio cholerae
J. Inorg. Biochem.
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1366-1372
2008
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-
-
-
1
-
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1
1
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3
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-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
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712274
Lin
Quinone reduction by the Na+-t ...
Vibrio cholerae, Vibrio cholerae O395 N1
J. Bacteriol.
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3902-3908
2007
-
-
-
-
-
-
2
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1
1
-
2
-
5
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-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
6
-
-
1
-
-
-
6
-
-
-
1
2
-
-
1
1
-
2
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
671141
Tao
Crystallization of the NADH-ox ...
Vibrio cholerae
Acta Crystallogr. Sect. F
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110-112
2006
-
-
-
1
-
-
-
-
1
1
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-
-
3
-
-
1
-
-
-
-
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1
1
-
-
-
-
-
-
-
3
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-
-
-
-
3
1
-
-
-
-
-
-
1
1
-
-
-
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1
-
-
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1
1
-
-
-
-
-
-
-
-
-
-
-
-
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-
671351
Brandt
Energy converting NADH:quinone ...
Arabidopsis thaliana, Bos taurus, Caenorhabditis elegans, Chlamydomonas reinhardtii, Drosophila melanogaster, Escherichia coli, Homo sapiens, Klebsiella pneumoniae, Mus musculus, Neurospora crassa, Oryza sativa, Paracoccus denitrificans, Rhodomonas salina, Thermus thermophilus, Yarrowia lipolytica
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93
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15
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42
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15
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60
15
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-
-
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45
-
-
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15
-
45
-
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93
-
-
15
15
-
42
-
-
-
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60
15
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-
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672135
Bogachev
Thermodynamic properties of th ...
Vibrio harveyi
Biochemistry
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3421-3428
2006
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1
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1
1
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1
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1
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-
-
-
-
1
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-
-
-
-
-
-
2
-
-
-
-
-
1
2
-
-
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
-
1
-
-
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674274
Vgenopoulou
Specific modification of a Na+ ...
Klebsiella pneumoniae
J. Bacteriol.
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3264-3272
2006
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-
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2
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1
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1
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1
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-
-
2
-
2
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
2
-
-
1
-
-
-
-
-
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1
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2
-
2
1
-
-
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1
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674705
Barquera
A new flavin radical signal in ...
Vibrio cholerae
J. Biol. Chem.
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36482-36491
2006
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-
2
-
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1
1
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1
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-
-
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-
1
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
2
-
-
-
-
-
1
1
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
672293
Bogachev
Na(+)-translocating NADH:quino ...
Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis, Porphyromonas gingivalis, Pseudomonas aeruginosa, Salinivibrio costicola, Shewanella putrefaciens, Vibrio alginolyticus, Vibrio harveyi, Yersinia pestis
Biochemistry (Moscow)
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143-149
2005
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34
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14
6
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11
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11
1
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33
1
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-
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-
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33
-
-
-
-
34
1
-
-
14
6
-
-
-
-
-
-
-
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-
11
1
-
-
-
-
-
-
-
-
-
-
-
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674443
Lin
A vertebrate-type ferredoxin d ...
Vibrio cholerae, Vibrio cholerae ATCC 39315
J. Biol. Chem.
280
22560-22563
2005
-
-
-
-
-
-
-
-
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1
-
-
-
5
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
711269
Bogachev
Na+-translocating NADH:quinone ...
Haemophilus influenzae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis, Porphyromonas gingivalis, Pseudomonas aeruginosa, Shewanella putrefaciens, Vibrio alginolyticus, Vibrio cholerae, Vibrio harveyi, Yersinia pestis
Biochemistry
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143-149
2005
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1
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22
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-
11
6
22
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11
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-
-
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22
11
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-
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66
-
-
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1
-
66
-
-
-
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22
-
-
-
11
6
22
-
-
-
-
-
-
-
-
22
11
-
-
-
-
-
-
-
-
-
-
-
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-
658029
Barquera
Mutagenesis study of the 2Fe-2 ...
Vibrio cholerae, Vibrio cholerae ATCC 39315
Biochemistry
43
12322-12330
2004
-
-
1
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7
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-
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1
-
2
-
8
-
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1
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-
-
-
-
5
-
-
-
-
-
-
-
-
5
-
-
-
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-
1
9
-
13
-
-
-
-
-
-
1
-
2
-
-
-
1
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
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-
-
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659342
Trk
NADH oxidation by the Na+-tran ...
Vibrio cholerae, Vibrio cholerae ATCC 39315
J. Biol. Chem.
279
21349-21355
2004
-
-
-
-
-
-
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1
-
-
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7
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
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-
-
658968
Barquera
X- and W-band EPR and Q-band E ...
Vibrio cholerae
J. Am. Chem. Soc.
125
265-275
2003
-
-
-
-
-
-
-
-
-
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1
-
1
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-
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-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392715
Barquera
Purification and characterizat ...
Vibrio cholerae
Biochemistry
41
3781-3789
2002
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-
1
-
-
-
-
-
1
1
1
1
-
2
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-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
4
-
-
-
-
-
1
4
-
-
-
-
-
-
-
1
1
1
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
658163
Bogachev
Kinetics of the spectral chang ...
Vibrio harveyi
Biochim. Biophys. Acta
1556
113-120
2002
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
392712
Steuber
Na+ translocation by bacterial ...
Escherichia coli, Klebsiella pneumoniae, Vibrio alginolyticus
Biochim. Biophys. Acta
1505
45-56
2001
-
-
-
-
-
-
-
-
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2
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4
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6
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-
-
-
-
-
7
-
-
-
-
-
-
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392713
Bogachev
: Sodium-dependent steps in th ...
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711996
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FMN is covalently attached to ...
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711995
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Covalently bound flavin in the ...
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392695
Pfenninger-Li
NADH:ubiquinone oxidoreductase ...
Vibrio alginolyticus
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711992
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Existence of Na+-translocating ...
Haemophilus influenzae, Haemophilus influenzae Rd, ATCC 51907
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711991
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392716
Tokuda
Na+ is translocated at NADH:qu ...
Vibrio alginolyticus
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1984
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