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Literature summary for 7.2.1.1 extracted from

  • Beattie, P.; Tan, K.; Bourne, R.M.; Leach, D.; Rich, P.R.; Ward, F.B.
    Cloning and sequencing of four structural genes for the Na+-translocating NADH-ubiquinone oxidoreductase of Vibrio alginolyticus (1994), FEBS Lett., 356, 333-338.
    View publication on PubMed
Search for more literature for 7.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
2-n-heptyl-4-hydroxyquinoline N-oxide
-
 Vibrio alginolyticus
Ag+
-
 Vibrio alginolyticus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Vibrio alginolyticus 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
22602
-
 1 * 48622 + 1 * 46809 + 1 * 27672 + 1 * 22602, subunits NqrA, NqrB, NqrC and NqrD, calculated from amino acid sequence Vibrio alginolyticus
27672
-
 1 * 48622 + 1 * 46809 + 1 * 27672 + 1 * 22602, subunits NqrA, NqrB, NqrC and NqrD, calculated from amino acid sequence Vibrio alginolyticus
46809
-
 1 * 48622 + 1 * 46809 + 1 * 27672 + 1 * 22602, subunits NqrA, NqrB, NqrC and NqrD, calculated from amino acid sequence Vibrio alginolyticus
48622
-
 1 * 48622 + 1 * 46809 + 1 * 27672 + 1 * 22602, subunits NqrA, NqrB, NqrC and NqrD, calculated from amino acid sequence Vibrio alginolyticus
254000
-
 gel filtration Vibrio alginolyticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deamino-NADH + H+ + ubiquinone + n Na+/in Vibrio alginolyticus
-
 deamino-NAD+ + ubiquinol + n Na+/out
-
 ?
deamino-NADH + H+ + ubiquinone + n Na+/in Vibrio alginolyticus NCIMB 11038
-
 deamino-NAD+ + ubiquinol + n Na+/out
-
 ?
NADH + H+ + ubiquinone + n Na+/in Vibrio alginolyticus
-
 NAD+ + ubiquinol + n Na+/out
-
 ?
NADH + H+ + ubiquinone + n Na+/in Vibrio alginolyticus NCIMB 11038
-
 NAD+ + ubiquinol + n Na+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio alginolyticus
-
-
-
Vibrio alginolyticus NCIMB 11038
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partially purified by DEAE Sepharose column chromatography and preparative gel electrophoresis Vibrio alginolyticus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deamino-NADH + H+ + ubiquinone + n Na+/in
-
 Vibrio alginolyticus deamino-NAD+ + ubiquinol + n Na+/out
-
 ?
deamino-NADH + H+ + ubiquinone + n Na+/in
-
 Vibrio alginolyticus NCIMB 11038 deamino-NAD+ + ubiquinol + n Na+/out
-
 ?
NADH + H+ + ubiquinone + n Na+/in
-
 Vibrio alginolyticus NAD+ + ubiquinol + n Na+/out
-
 ?
NADH + H+ + ubiquinone + n Na+/in
-
 Vibrio alginolyticus NCIMB 11038 NAD+ + ubiquinol + n Na+/out
-
 ?

Subunits

Subunits Comment Organism
heterotetramer 1 * 48622 + 1 * 46809 + 1 * 27672 + 1 * 22602, subunits NqrA, NqrB, NqrC and NqrD, calculated from amino acid sequence Vibrio alginolyticus

Synonyms

Synonyms Comment Organism
Na+-translocating NADH-ubiquinone oxidoreductase
-
 Vibrio alginolyticus
NaΒ’-dependent NADH-ubiquinone oxidoreductase
-
 Vibrio alginolyticus
NqrA subunit Vibrio alginolyticus
NqrB subunit Vibrio alginolyticus
NqrC subunit Vibrio alginolyticus
NqrD subunit Vibrio alginolyticus

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Vibrio alginolyticus
FMN
-
 Vibrio alginolyticus
NADH
-
 Vibrio alginolyticus
[2Fe-2S]-center
-
 Vibrio alginolyticus

pI Value

Organism Comment pI Value Maximum pI Value
Vibrio alginolyticus subunit NqrC, calculated from amino acid sequence
-
 4.9
Vibrio alginolyticus subunit NqrA, calculated from amino acid sequence
-
 5.6
Vibrio alginolyticus subunit NqrB, calculated from amino acid sequence
-
 9.1
Vibrio alginolyticus subunit NqrD, calculated from amino acid sequence
-
 9.3