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Literature summary for 7.2.1.1 extracted from

  • Bogachev, A.V.; Verkhovsky, M.I.
    Na(+)-translocating NADH:quinone oxidoreductase: progress achieved and prospects of investigations (2005), Biochemistry (Moscow), 70, 143-149.
    View publication on PubMed
Search for more literature for 7.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
2-heptyl-4-hydroxyquinoline N-oxide
-
 Haemophilus influenzae
2-heptyl-4-hydroxyquinoline N-oxide
-
 Klebsiella pneumoniae
2-heptyl-4-hydroxyquinoline N-oxide
-
 Neisseria gonorrhoeae
2-heptyl-4-hydroxyquinoline N-oxide
-
 Neisseria meningitidis
2-heptyl-4-hydroxyquinoline N-oxide
-
 Porphyromonas gingivalis
2-heptyl-4-hydroxyquinoline N-oxide
-
 Pseudomonas aeruginosa
2-heptyl-4-hydroxyquinoline N-oxide
-
 Salinivibrio costicola
2-heptyl-4-hydroxyquinoline N-oxide
-
 Shewanella putrefaciens
2-heptyl-4-hydroxyquinoline N-oxide
-
 Vibrio alginolyticus
2-heptyl-4-hydroxyquinoline N-oxide
-
 Vibrio harveyi
2-heptyl-4-hydroxyquinoline N-oxide
-
 Yersinia pestis
Ag+
-
 Salinivibrio costicola
Ag+
-
 Vibrio alginolyticus
Ag2+
-
 Vibrio harveyi
Cd2+
-
 Salinivibrio costicola
Cd2+
-
 Vibrio alginolyticus
Cd2+
-
 Vibrio harveyi
Cu2+
-
 Salinivibrio costicola
Cu2+
-
 Vibrio alginolyticus
Cu2+
-
 Vibrio harveyi
korormicin
-
 Haemophilus influenzae
korormicin
-
 Klebsiella pneumoniae
korormicin
-
 Neisseria gonorrhoeae
korormicin
-
 Neisseria meningitidis
korormicin
-
 Porphyromonas gingivalis
korormicin
-
 Pseudomonas aeruginosa
korormicin
-
 Salinivibrio costicola
korormicin
-
 Shewanella putrefaciens
korormicin
-
 Vibrio alginolyticus
korormicin
-
 Vibrio harveyi
korormicin
-
 Yersinia pestis
Zn2+
-
 Salinivibrio costicola
Zn2+
-
 Vibrio alginolyticus
Zn2+
-
 Vibrio harveyi

Metals/Ions

Metals/Ions Comment Organism Structure
Na+ stimulates enzyme activity Vibrio harveyi
Na+ stimulates enzyme activity Salinivibrio costicola
Na+ stimulates enzyme activity Vibrio alginolyticus
[2Fe-2S] noncovalently bound to subunit NqrF Haemophilus influenzae
[2Fe-2S] noncovalently bound to subunit NqrF Vibrio harveyi
[2Fe-2S] noncovalently bound to subunit NqrF Pseudomonas aeruginosa
[2Fe-2S] noncovalently bound to subunit NqrF Neisseria gonorrhoeae
[2Fe-2S] noncovalently bound to subunit NqrF Neisseria meningitidis
[2Fe-2S] noncovalently bound to subunit NqrF Klebsiella pneumoniae
[2Fe-2S] noncovalently bound to subunit NqrF Yersinia pestis
[2Fe-2S] noncovalently bound to subunit NqrF Salinivibrio costicola
[2Fe-2S] noncovalently bound to subunit NqrF Porphyromonas gingivalis
[2Fe-2S] noncovalently bound to subunit NqrF Vibrio alginolyticus
[2Fe-2S] noncovalently bound to subunit NqrF Shewanella putrefaciens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
21500
-
 subunit NqrE Vibrio harveyi
22700
-
 subunit NqrD Vibrio harveyi
27500
-
 subunit NqrC Vibrio harveyi
45200
-
 subunit NqrF Vibrio harveyi
45400
-
 subunit NqrB Vibrio harveyi
48400
-
 subunit NqrA Vibrio harveyi

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-
Klebsiella pneumoniae
-
-
-
Neisseria gonorrhoeae
-
-
-
Neisseria meningitidis
-
-
-
Porphyromonas gingivalis
-
-
-
Pseudomonas aeruginosa
-
-
-
Salinivibrio costicola
-
-
-
Shewanella putrefaciens
-
-
-
Vibrio alginolyticus
-
-
-
Vibrio harveyi
-
-
-
Yersinia pestis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone + Na+/in
-
 Haemophilus influenzae NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Vibrio harveyi NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Pseudomonas aeruginosa NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Neisseria gonorrhoeae NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Neisseria meningitidis NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Klebsiella pneumoniae NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Yersinia pestis NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Salinivibrio costicola NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Porphyromonas gingivalis NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Vibrio alginolyticus NAD+ + ubiquinol + Na+/out
-
 ?
NADH + ubiquinone + Na+/in
-
 Shewanella putrefaciens NAD+ + ubiquinol + Na+/out
-
 ?

Subunits

Subunits Comment Organism
hexamer 1 * 48400, 1 * 45400, 1 * 27500, 1 * 22700, 1 * 21500, 1 * 45200 Vibrio harveyi

Synonyms

Synonyms Comment Organism
Na(+)-translocating NADH:quinone oxidoreductase
-
 Haemophilus influenzae
Na(+)-translocating NADH:quinone oxidoreductase
-
 Vibrio harveyi
Na(+)-translocating NADH:quinone oxidoreductase
-
 Pseudomonas aeruginosa
Na(+)-translocating NADH:quinone oxidoreductase
-
 Neisseria gonorrhoeae
Na(+)-translocating NADH:quinone oxidoreductase
-
 Neisseria meningitidis
Na(+)-translocating NADH:quinone oxidoreductase
-
 Klebsiella pneumoniae
Na(+)-translocating NADH:quinone oxidoreductase
-
 Yersinia pestis
Na(+)-translocating NADH:quinone oxidoreductase
-
 Salinivibrio costicola
Na(+)-translocating NADH:quinone oxidoreductase
-
 Porphyromonas gingivalis
Na(+)-translocating NADH:quinone oxidoreductase
-
 Vibrio alginolyticus
Na(+)-translocating NADH:quinone oxidoreductase
-
 Shewanella putrefaciens
Na+-NQR
-
 Haemophilus influenzae
Na+-NQR
-
 Vibrio harveyi
Na+-NQR
-
 Pseudomonas aeruginosa
Na+-NQR
-
 Neisseria gonorrhoeae
Na+-NQR
-
 Neisseria meningitidis
Na+-NQR
-
 Klebsiella pneumoniae
Na+-NQR
-
 Yersinia pestis
Na+-NQR
-
 Salinivibrio costicola
Na+-NQR
-
 Porphyromonas gingivalis
Na+-NQR
-
 Vibrio alginolyticus
Na+-NQR
-
 Shewanella putrefaciens

Cofactor

Cofactor Comment Organism Structure
FAD noncovalently bound to subunit NqrF Haemophilus influenzae
FAD noncovalently bound to subunit NqrF Vibrio harveyi
FAD noncovalently bound to subunit NqrF Pseudomonas aeruginosa
FAD noncovalently bound to subunit NqrF Neisseria gonorrhoeae
FAD noncovalently bound to subunit NqrF Neisseria meningitidis
FAD noncovalently bound to subunit NqrF Klebsiella pneumoniae
FAD noncovalently bound to subunit NqrF Yersinia pestis
FAD noncovalently bound to subunit NqrF Salinivibrio costicola
FAD noncovalently bound to subunit NqrF Porphyromonas gingivalis
FAD noncovalently bound to subunit NqrF Vibrio alginolyticus
FAD noncovalently bound to subunit NqrF Shewanella putrefaciens
FMN covalently bound to subunits NqrB and NqrC Haemophilus influenzae
FMN covalently bound to subunits NqrB and NqrC Vibrio harveyi
FMN covalently bound to subunits NqrB and NqrC Pseudomonas aeruginosa
FMN covalently bound to subunits NqrB and NqrC Neisseria gonorrhoeae
FMN covalently bound to subunits NqrB and NqrC Neisseria meningitidis
FMN covalently bound to subunits NqrB and NqrC Klebsiella pneumoniae
FMN covalently bound to subunits NqrB and NqrC Yersinia pestis
FMN covalently bound to subunits NqrB and NqrC Salinivibrio costicola
FMN covalently bound to subunits NqrB and NqrC Porphyromonas gingivalis
FMN covalently bound to subunits NqrB and NqrC Vibrio alginolyticus
FMN covalently bound to subunits NqrB and NqrC Shewanella putrefaciens
NADH
-
 Vibrio harveyi
NADH
-
 Vibrio alginolyticus
NADH specific for NADH Haemophilus influenzae
NADH specific for NADH Pseudomonas aeruginosa
NADH specific for NADH Neisseria gonorrhoeae
NADH specific for NADH Neisseria meningitidis
NADH specific for NADH Klebsiella pneumoniae
NADH specific for NADH Yersinia pestis
NADH specific for NADH Salinivibrio costicola
NADH specific for NADH Porphyromonas gingivalis
NADH specific for NADH Shewanella putrefaciens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000001
-
 korormicin
-
 Vibrio harveyi