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Literature summary for 7.1.2.2 extracted from

  • La, T.; Clark-Walker, G.D.; Wang, X.; Wilkens, S.; Chen, X.J.
    Mutations on the N-terminal edge of the DELSEED loop in either the alpha or beta subunit of the mitochondrial F1-ATPase enhance ATP hydrolysis in the absence of the central gamma rotor (2013), Eukaryot. Cell, 12, 1451-1461.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
mutant enzymes are expressed in Kluyveromyces lactis mutant lacking the gamma rotor Kluyveromyces lactis

Protein Variants

Protein Variants Comment Organism
F446I the mutation in the alpha subunit suppresses cell death by the loss of mitochondrial DNA in a Kluyveromyces lactis mutant lacking the gamma rotor subunit Kluyveromyces lactis
G419D the mutation in the beta subunit suppresses cell death by the loss of mitochondrial DNA in a Kluyveromyces lactis mutant lacking the gamma rotor subunit Kluyveromyces lactis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Kluyveromyces lactis
-
 ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in Kluyveromyces lactis PM6-7A
-
 ADP + phosphate + H+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Kluyveromyces lactis
-
-
-
Kluyveromyces lactis PM6-7A
-
-
-

Purification (Commentary)

Purification (Comment) Organism
nickel affinity column chromatography and gel filtration Kluyveromyces lactis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Kluyveromyces lactis ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in
-
 Kluyveromyces lactis PM6-7A ADP + phosphate + H+/out
-
 ?

Synonyms

Synonyms Comment Organism
F1-ATPase
-
 Kluyveromyces lactis