Inhibitors | Comment | Organism | Structure |
---|---|---|---|
bafilomycin A1 | - |
Mus musculus | |
Ca2+ | extracellular, inhibits the enzym ein osteoclast membranes, Ca2+ behaves as a negative feedback signal for osteoclast function | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
plasma membrane | high enzyme content in the ruffled membrane facing the the bone surface | Mus musculus | 5886 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in | Mus musculus | - |
ADP + phosphate + H+/out | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
osteoclast | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in | - |
Mus musculus | ADP + phosphate + H+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
plasma membrane V-ATPase | - |
Mus musculus |
plasma membrane vacuolar H+-ATPase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
additional information | Ca2+ facilitates a dynamin- and V-ATPase-dependent endocytosis in association with with an inhibition of the plasma membrane V-ATPase, overview | Mus musculus |
physiological function | the protons secreted by the enzyme in osteoclast membrane into the closed extracellular compartment are essential for demineralization of calcified bone | Mus musculus |