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Literature summary for 7.1.2.2 extracted from

  • Liang, Y.; Ackerman, S.H.
    Characterization of mutation in the beta subunit of the mitochondrial F1-ATPase that produce defects in enzyme catalysis and assembly (1996), J. Biol. Chem., 271, 26522-26528.
    View publication on PubMed
Search for more literature for 7.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
ATP2 gene, coding for the beta subunit of the mitochondrial F1-ATPase Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
E222K modification of beta-subunit, mutation assembles an F1 of normal size that is catalytically inactive Saccharomyces cerevisiae
G133D modification of beta-subunit, mutation correlates with an assembly-defective phenotype that is characterized by the acumulation of the F1 alpha and beta subunits in large protein aggregates Saccharomyces cerevisiae
G227D modification of beta-subunit, mutation correlates with an assembly-defective phenotype that is characterized by the acumulation of the F1 alpha and beta subunits in large protein aggregates Saccharomyces cerevisiae
P179L modification of beta subunit, mutation correlates with an assembly-defective phenotype that is characterized by the acumulation of the F1 alpha and beta subunits in large protein aggregates Saccharomyces cerevisiae
R293K modification of beta-subunit, mutation assembles an F1 of normal size that is catalytically inactive Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Saccharomyces cerevisiae 5739
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Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P00830
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
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 Saccharomyces cerevisiae ADP + phosphate + H+/out
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 ?
additional information Gly133 of beta subunit is important for structural stability, Glu222 and Arg293 are important for catalytic cooperativity Saccharomyces cerevisiae ?
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 ?