Protein Variants | Comment | Organism |
---|---|---|
D714A | 5fold decrease in expression, loss of catalytic activity | Saccharomyces cerevisiae |
D714C | mutation blocks trafficking, enzyme is not delivered to secretory vesicles. 4% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D714E | 12% of wild-type expression, 7% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D714N | 67% of wild-type expression, 97% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D718A | 79% of wild-type expression, 104% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D718C | 84% of wild-type expression, 108% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D720A | 65% of wild-type expression, 47% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D720C | 85% of wild-type expression, 80% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D720E | 61% of wild-type expression, 87% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
D720N | 72% of wild-type expression, 88% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
I719A | 3fold reduction in coupling ratio between ATP hydrolysis and H+ transport | Saccharomyces cerevisiae |
I719C | mutant is similar to wild-type | Saccharomyces cerevisiae |
L717A | mutation blocks trafficking, enzyme is not delivered to secretory vesicles | Saccharomyces cerevisiae |
L717C | mutation blocks trafficking, enzyme is not delivered to secretory vesicles | Saccharomyces cerevisiae |
N715A | 68% of wild-type expression, 71% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
N715C | 88% of wild-type expression, 58% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
S716A | 71% of wild-type expression, 60% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
S716C | 95% of wild-type expression, 101% of wild-type ATP hydrolysis | Saccharomyces cerevisiae |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
vanadate | - |
Saccharomyces cerevisiae |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.5 | - |
ATP | mutant D720C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.5 | - |
ATP | mutant S716A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.6 | - |
ATP | mutant N715A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.7 | - |
ATP | mutant D720A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.7 | - |
ATP | mutant D720E, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.9 | - |
ATP | mutant D714N, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.9 | - |
ATP | mutant D720N, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
1 | - |
ATP | mutant I719A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
1 | - |
ATP | mutant S716C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
1.1 | - |
ATP | mutant D718A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
1.2 | - |
ATP | mutant I719C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
1.3 | - |
ATP | wild-type, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
1.6 | - |
ATP | mutant N715C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
2.8 | - |
ATP | mutant D718C, 30°C, pH 5.7 | Saccharomyces cerevisiae |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Saccharomyces cerevisiae | - |
- |
- |
Saccharomyces cerevisiae SY4 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in | - |
Saccharomyces cerevisiae | ADP + phosphate + H+/out | - |
? | |
ATP + H2O + H+/in | - |
Saccharomyces cerevisiae SY4 | ADP + phosphate + H+/out | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PMA1 | - |
Saccharomyces cerevisiae |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
vanadate | mutant I719C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.001 | - |
vanadate | mutant N715C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.001 | - |
vanadate | mutant S716C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0011 | - |
vanadate | mutant D718C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0012 | - |
vanadate | mutant N715A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0012 | - |
vanadate | mutant S716A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0019 | - |
vanadate | mutant D720C, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.002 | - |
vanadate | mutant I719A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0027 | - |
vanadate | wild-type, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0033 | - |
vanadate | mutant D714N, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0035 | - |
vanadate | mutant D720E, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0037 | - |
vanadate | mutant D718A, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0037 | - |
vanadate | mutant D720N, 30°C, pH 5.7 | Saccharomyces cerevisiae | |
0.0055 | - |
vanadate | mutant D720A, 30°C, pH 5.7 | Saccharomyces cerevisiae |