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Literature summary for 7.1.2.1 extracted from

  • Billack, B.; Santoro, M.; Lau-Cam, C.
    Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase (2009), Microb. Drug Resist., 15, 77-83.
    View publication on PubMed
Search for more literature for 7.1.2.1

Inhibitors

Inhibitors Comment Organism Structure
2-phenyl-1,2-benzisoselenazol-3(2H)-one i.e. ebselen, a synthetic selenium-containing compound with antimicrobial activity. It acts fungicidally against Candida albicans at 0.030 mM, effect of ebselen on the growth of the strain, overview Candida albicans
2-phenyl-1,2-benzisoselenazol-3(2H)-one i.e. ebselen, a synthetic selenium-containing compound with antimicrobial activity, effect of ebselen on the growth of the strain, overview; i.e. ebselen, a synthetic selenium-containing compound with antimicrobial activity, effect of ebselen on the growth of the strain, overview. The antifungal action of ebselen is related, at least in part, to its ability to interact with L-cysteine, high affinity of selenium for sulfhydryl groups Saccharomyces cerevisiae
additional information ebselen is at least 10fold more potent as antifungal compound compared the azoles fluconazole, itraconazole, and ketoconatzole, and as amphotericin B Candida albicans

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Saccharomyces cerevisiae 5886
-
plasma membrane
-
 Candida albicans 5886
-

Organism

Organism UniProt Comment Textmining
Candida albicans
-
 a fluconazole-resistant strain, gene PMA1
-
Candida albicans ATCC 96901
-
 a fluconazole-resistant strain, gene PMA1
-
Saccharomyces cerevisiae
-
 gene PMA1
-
Saccharomyces cerevisiae AH109
-
 gene PMA1
-
Saccharomyces cerevisiae CG1945
-
 gene PMA1
-
Saccharomyces cerevisiae EGY48
-
 gene PMA1
-

Source Tissue

Source Tissue Comment Organism Textmining

Synonyms

Synonyms Comment Organism
plasma membrane H+-ATPase
-
 Saccharomyces cerevisiae
plasma membrane H+-ATPase
-
 Candida albicans
Pma1p
-
 Saccharomyces cerevisiae
Pma1p
-
 Candida albicans

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Saccharomyces cerevisiae
30
-
 assay at Candida albicans

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.003
-
 pH not specified in the publication, 30°C Saccharomyces cerevisiae 2-phenyl-1,2-benzisoselenazol-3(2H)-one
0.006
-
 pH not specified in the publication, 30°C Candida albicans 2-phenyl-1,2-benzisoselenazol-3(2H)-one