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Literature summary for 7.1.2.1 extracted from

  • Billack, B.; Pietka-Ottlik, M.; Santoro, M.; Nicholson, S.; Mlochowski, J.; Lau-Cam, C.
    Evaluation of the antifungal and plasma membrane H+-ATPase inhibitory action of ebselen and two ebselen analogs in S. cerevisiae cultures (2010), J. Enzyme Inhib. Med. Chem., 25, 312-317.
    View publication on PubMed
Search for more literature for 7.1.2.1

Inhibitors

Inhibitors Comment Organism Structure
2-(3-pyridinyl)-1,2-benzisoselenazol-3(2H)-one an ebselen analogue Saccharomyces cerevisiae
2-phenyl-1,2-benzisoselenazol-3(2H)-one i.e. ebselen Saccharomyces cerevisiae
2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide an ebselen analogue Saccharomyces cerevisiae
nitrate
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
plasma membrane
-
 Saccharomyces cerevisiae 5886
-
vacuole
-
 Saccharomyces cerevisiae 5773
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Saccharomyces cerevisiae
-
 ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in Saccharomyces cerevisiae AH109
-
 ADP + phosphate + H+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae
-
 strain AH109
-
Saccharomyces cerevisiae AH109
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Saccharomyces cerevisiae ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in
-
 Saccharomyces cerevisiae AH109 ADP + phosphate + H+/out
-
 ?

Synonyms

Synonyms Comment Organism
plasma membrane H*-ATPase pump
-
 Saccharomyces cerevisiae
Pma1p
-
 Saccharomyces cerevisiae
vacuolar ATPase
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0025
-
 pH 6.5, 30°C Saccharomyces cerevisiae 2-phenyl-1,2-benzisoselenazol-3(2H)-one
0.004
-
 pH 6.5, 30°C Saccharomyces cerevisiae 2-phenyl-1,2-benzisoselenazol-3(2H)-one 1-oxide
0.0067
-
 pH 6.5, 30°C Saccharomyces cerevisiae 2-(3-pyridinyl)-1,2-benzisoselenazol-3(2H)-one

General Information

General Information Comment Organism
physiological function the high capacity proton pump Pma1p plays a critical role in the intracellular regulation of pH and in nutrient uptake of yeast Saccharomyces cerevisiae