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Literature summary for 7.1.1.9 extracted from

  • Unitt, D.; Hollis, V.; Palacios-Callender, M.; Frakich, N.; Moncada, S.
    Inactivation of nitric oxide by cytochrome c oxidase under steady-state oxygen conditions (2010), Biochim. Biophys. Acta, 1797, 371-377.
    View publication on PubMed
Search for more literature for 7.1.1.9

Inhibitors

Inhibitors Comment Organism Structure
nitric oxide nitric oxide that is not inactivated inhibits the cytochrome c oxidase, reducing the enzyme and lowering O2 consumption Homo sapiens
Sodium azide the addition of 0.5 mM sodium azide at 0.1 mM O2during the initial purging process results in a maximal reduction in cytochrome c oxidase redox state Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ferricytochrome c + H2O Homo sapiens
-
 ferrocytochrome c + O2 + H+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryonic kidney
-
 Homo sapiens
-
Tet-iNOS-293 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferricytochrome c + H2O
-
 Homo sapiens ferrocytochrome c + O2 + H+
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome c oxidase
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the cytochrome c oxidase plays an important role in regulating endogenous nitric oxide concentrations Homo sapiens