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Literature summary for 7.1.1.9 extracted from
- Nitrite-mediated antagonism of cyanide inhibition of cytochrome c oxidase in dopamine neurons (2010), Toxicol. Sci., 115, 569-576.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| nitric oxide | nitric oxide generated from NaNO2 decreases cellular oxygen consumption and inhibits CcOX activity | Rattus norvegicus |  |
| potassium cyanide | cyanide binds to the binuclear heme center of cytochrome c oxidase, complete inhibition at 0.02 mM, pretreatment with NaNO2 reverses potassium cyanide-mediated inhibition of CcOX activity | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| N-27 cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ferrocytochrome c + O2 + H+ | - |
Rattus norvegicus | ferricytochrome c + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CcOX | - |
Rattus norvegicus |
| cytochrome c oxidase | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| heme | binuclear heme center | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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