Literature summary for 7.1.1.9 extracted from

Vaz, A.R.; Delgado-Esteban, M.; Brito, M.A.; Bolanos, J.P.; Brites, D.; Almeida, A.
Bilirubin selectively inhibits cytochrome c oxidase activity and induces apoptosis in immature cortical neurons: assessment of the protective effects of glycoursodeoxycholic acid (2010), J. Neurochem., 112, 56-65.

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Inhibitors

Inhibitors	Comment	Organism	Structure
bilirubin	0.05 mM serum unconjugated bilirubin rapidly and selectively inhibits cytochrome c oxidase activity. Pre-treatment of neurons with 0.05 mM glycoursodeoxycholic acid prior to exposure to serum unconjugated bilirubin prevents inhibition of cytrochrome c oxidase activity	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ferrocytochrome c + O2 + H+	Rattus norvegicus	-	ferricytochrome c + H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
neuron	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ferrocytochrome c + O2 + H+	-	Rattus norvegicus	ferricytochrome c + H2O	-	?

Synonyms

Synonyms	Comment	Organism
complex IV	-	Rattus norvegicus
cytochrome c oxidase	-	Rattus norvegicus

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Release 2023.1 (January 2023)