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Literature summary for 7.1.1.9 extracted from
- Cyanide inhibition and pyruvate-induced recovery of cytochrome c oxidase (2010), J. Bioenerg. Biomembr., 42, 395-403.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| potassium cyanide | 0.25 mM potassium cyanide completely and reversibly inhibits both the electron and proton transport function of COX, the addition of 60 mM pyruvate induces the maximal recovery of both parameters to 60-80% of the original values. Low KCN concentrations of up to 0.005 mM lead to a profound, 30fold decrease of COX affinity for oxygen | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ferrocytochrome c + O2 + H+ | Rattus norvegicus | - |
ferricytochrome c + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ferrocytochrome c + O2 + H+ | - |
Rattus norvegicus | ferricytochrome c + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COX | - |
Rattus norvegicus |
| cytochrome c oxidase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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