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Literature summary for 7.1.1.9 extracted from

  • Li, Y.; DAurelio, M.; Deng, J.H.; Park, J.S.; Manfredi, G.; Hu, P.; Lu, J.; Bai, Y.
    An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria (2007), J. Biol. Chem., 282, 17557-17562.
    View publication on PubMed
Search for more literature for 7.1.1.9

Application

Application Comment Organism
additional information an assembled complex IV helps to maintain complex I (NADH-ubiquinone oxidoreductase) in mammalian cells Mus musculus
additional information an assembled complex IV helps to maintain complex I (NADH-ubiquinone oxidoreductase) in mammalian cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
G6930A nonsense mutation in the mitochondrially encoded complex IV subunit 1 gene, which causes a disruption in the assembly and defective activity of complex VI Homo sapiens
additional information an assembled complex IV is required to maintain the stability of complex I in a mouse cell line with suppressed expression of subunit 4 of complex IV Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
potassium cyanide 2 mM inhibits electron flow from complex IV to oxygen Mus musculus
Sodium azide 5 mM inhibits electron flow from complex IV to oxygen Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
143B cell
-
 Homo sapiens
-
A-9 cell
-
 Mus musculus
-
additional information in C1 cells, C2 cells and C3 cells steady state level of complex I is significantly reduced due to a defective assembly of complex IV. Also present in 4A cells Mus musculus
-
osteosarcoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
reduced cytochrome c + O2 + H+
-
 Mus musculus oxidized cytochrome c + H2O
-
 ?
reduced cytochrome c + O2 + H+
-
 Homo sapiens oxidized cytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
COX I
-
 Mus musculus
COX IV
-
 Mus musculus
COX IV
-
 Homo sapiens
cytochrome c oxidase
-
 Mus musculus
cytochrome c oxidase
-
 Homo sapiens