Literature summary for 7.1.1.9 extracted from

Zuckerbraun, B.S.; Chin, B.Y.; Bilban, M.; dAvila, J.C.; Rao, J.; Billiar, T.R.; Otterbein, L.E.
Carbon monoxide signals via inhibition of cytochrome c oxidase and generation of mitochondrial reactive oxygen species (2007), FASEB J., 21, 1099-1106.

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Inhibitors

Inhibitors	Comment	Organism	Structure
CO	inhibits cytochrome c oxidase activity by 50%. Acts via inhibition of cytochrome c oxidase leading to the generation of low levels of reactive oxygen species that in turn mediate subsequent adaptive signaling. CO inhibits cytochrome c oxidase, while maintaining cellular ATP levels and increasing mitochondrial membrane potential	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
RAW-264.7 cell	-	Mus musculus	-

Synonyms

Synonyms	Comment	Organism
cytochrome c oxidase	-	Mus musculus

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Release 2023.1 (January 2023)