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Literature summary for 7.1.1.9 extracted from
- Chronic brain cytochrome oxidase inhibition selectively alters hippocampal cholinergic innervation and impairs memory: prevention by ladostigil (2007), Exp. Neurol., 206, 209-219.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | after administering NaN3, chronic treatment with ladostigil prevents the decrease in choline acetyltransferase in the diagonal band, the compensatory increase in synaptic plasticity and transferrin receptors and the memory deficits without restoring COx activity | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the cholinesterase and monoamine oxidase inhibitor ladostigil may have a beneficial effect on cognitive deficits in Alzheimer's disease patients that have a reduction in cortical COx activity and cholinergic hypofunction | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NaN3 | reduces COx activity in homogenates of the cortex and hippocampus by 40% and 37% respectively, 4 weeks after pump implantation | Rattus norvegicus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
male sprague-dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Rattus norvegicus | - |
| hippocampus | - |
Rattus norvegicus | - |
| additional information | cortex | Rattus norvegicus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COX | - |
Rattus norvegicus |
| cytochrome oxidase | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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