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Literature summary for 7.1.1.9 extracted from

  • Barnett, M.; Lin, D.; Akoyev, V.; Willard, L.; Takemoto, D.
    Protein kinase C epsilon activates lens mitochondrial cytochrome c oxidase subunit IV during hypoxia (2008), Exp. Eye Res., 86, 226-234.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.9

Activating Compound

Activating Compound Comment Organism Structure
additional information protein kinase C epsilon activates under hypoxic conditions. CytCOx activity is increased by 5fold after hypoxia. Under normoxic conditions, in whole lenses, there is only a weak interaction between protein kinase C epsilon and CytCOx Mus musculus

Application

Application Comment Organism
medicine protein kinase C epsilon is activated by hypoxia, which results in the activation of the mitochondrial protein CytCOx, which can protect the lens from mitochondrial damage under naturally hypoxic conditions observed in this tissue Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 B6.129S4-Prkce/tm1/Msg/J mice and Prcke/tm1/Msg-2-3
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferrocytochrome c + O2 + H+
-
 Mus musculus ferricytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CytCOx
-
 Mus musculus
cytochrome c oxidase subunit IV
-
 Mus musculus