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Literature summary for 7.1.1.9 extracted from

  • Iheagwara, K.N.; Thom, S.R.; Deutschman, C.S.; Levy, R.J.
    Myocardial cytochrome oxidase activity is decreased following carbon monoxide exposure (2007), Biochim. Biophys. Acta, 1772, 1112-1116.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.9

Application

Application Comment Organism
medicine myocardial CcOX impairment can underlie CO induced cardiac dysfunction Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CO significantly decreases myocardial CcOX activity. CcOX I protein levels significantly decrease following CO exposure while enzyme turnover number and CcOX I mRNA levels remain unchanged. Decreased CcOX activity following CO inhalation is likely due to decreased heme aa3 and CcOX subunit I content Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.037
-
 ferrocytochrome c following sham exposure Mus musculus
0.041
-
 ferrocytochrome c following CO exposure Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male C57Bl6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
heart ventricle
-
 Mus musculus
-
myocardium
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferrocytochrome c + O2 + H+
-
 Mus musculus ferricytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CcOX
-
 Mus musculus
cytochrome oxidase
-
 Mus musculus