Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.1.1.9 extracted from

  • Luque-Ortega, J.R.; Rivas, L.
    Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes (2007), Antimicrob. Agents Chemother., 51, 1327-1332.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
miltefosine inhibits in a dose-dependent manner. CcO appears to be an important target, as inhibition by this drug runs parallel to the alteration of processes such as O2 consumption and mitochondrial membrane potential, as well as the drop in ATP levels Leishmania donovani

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Leishmania donovani 5739
-

Organism

Organism UniProt Comment Textmining
Leishmania donovani
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
promastigote
-
Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
reduced cytochrome c + O2 + H+
-
Leishmania donovani oxidized cytochrome c + H2O
-
?

Synonyms

Synonyms Comment Organism
CCO
-
Leishmania donovani
cytochrome c oxidase
-
Leishmania donovani