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Literature summary for 7.1.1.9 extracted from

  • Durham, S.E.; Samuels, D.C.; Cree, L.M.; Chinnery, P.F.
    Normal levels of wild-type mitochondrial DNA maintain cytochrome c oxidase activity for two pathogenic mitochondrial DNA mutations but not for m.3243A-->G (2007), Am. J. Hum. Genet., 81, 189-195.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information segments of human skeletal muscle fibers harboring two pathogenic mitochondrial DNA mutations retain normal COX activity by maintaining a minimum amount of wild-type mitochondrial DNA Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information high percentage levels of mutated mitochondrial DNA are associated with a dramatic reduction in wild-type levels and COX deficiency. For the m.3243ArG mutation, a superabundance of wild-type mitochondrial DNA is found in many muscle-fiber sections with negligible COX activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle fiber
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
COX
-
Homo sapiens
cytochrome c oxidase
-
Homo sapiens