Literature summary for 7.1.1.9 extracted from

Hargreaves, I.P.; Duncan, A.J.; Wu, L.; Agrawal, A.; Land, J.M.; Heales, S.J.
Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies (2007), Mitochondrion, 7, 284-287.

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Application

Application	Comment	Organism
medicine	evidence of secondary loss of electron transport chain function (loss of complex II-III activity) resulting from a primary electron transport chain deficiency (of complex IV), which provides a possible mechanism for the progressive nature of mitochondrial encephalomyopathies and why in some patients multiple patterns of electron transport chain deficiencies may be demonstrated	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
KCN	1 mM results in a sustained 50% loss of activity following 24, 48 and 72 h of culture	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
additional information	1321N cell	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
cytochrome oxidase	-	Homo sapiens

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Release 2023.1 (January 2023)