Literature summary for 7.1.1.9 extracted from

Nicholls, P.; Chance, B.
Cytochrome c oxidase (1974), Mol. Mech. Oxygen Activ. (Hayaishi, O., ed.) Academic Press, New York, , 479-534.

No PubMed abstract available

Search for more literature for 7.1.1.9

Inhibitors

Inhibitors	Comment	Organism	Structure
azide	-	Bos taurus
azide	heme-binding inhibitor, noncompetitive vs. O2 and cytochrome c	eukaryota
CN-	-	Bos taurus
CN-	heme-binding inhibitor, noncompetitive vs. O2 and cytochrome c	eukaryota
CO	competitive vs. O2	Bos taurus
CO	competitive vs. O2	eukaryota
F-	-	Bos taurus
F-	-	eukaryota
ferricytochrome c	-	eukaryota
NO	competitive vs. O2	Bos taurus
phosphate	-	Bos taurus
Sulfide	-	Bos taurus
Sulfide	heme-binding inhibitor, noncompetitive vs. O2 and cytochrome c	eukaryota

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.006	0.077	ferrocytochrome c	dependency on pH, phosphate and K+ concentration	Bos taurus

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
180000	280000	minimal molecular weight, calculated from subunit composition, heme content	eukaryota

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
eukaryota	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ferrocytochrome c + O2 + H+	-	Bos taurus	ferricytochrome c + H2O	-	r

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
40	-	-	Bos taurus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6	-	-	Bos taurus

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0035	-	ferricytochrome c	at pH 8.0	eukaryota
0.0079	-	ferricytochrome c	at pH 7.0	eukaryota
0.0083	-	ferricytochrome c	at pH 6.0	eukaryota

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Release 2023.1 (January 2023)