Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.1.1.9 extracted from

  • Chan, S.I.; Li, P.M.
    Cytochrome c oxidase: understanding natures design of a proton pump (1990), Biochemistry, 29, 1-12.
    View publication on PubMed
Search for more literature for 7.1.1.9

Cloned(Commentary)

Cloned (Comment) Organism
-
 Paracoccus denitrificans

Metals/Ions

Metals/Ions Comment Organism Structure
Cu
-
 Mammalia
Cu CuB located in subunit I, electron flow from ferrocytochrome c to binuclear center Paracoccus denitrificans
Cu CuB located in subunit I, electron flow from ferrocytochrome c to binuclear center Bacteria
Cu CuB located in subunit I, electron flow from ferrocytochrome c to binuclear center eukaryota
Cu CuA located in subunit II, binding of O2 and reduction Paracoccus denitrificans
Cu CuA located in subunit II, binding of O2 and reduction Bacteria
Cu CuA located in subunit II, binding of O2 and reduction eukaryota
Fe
-
 Mammalia
Fe
-
 Bacteria
Fe
-
 eukaryota
Mg
-
 Mammalia
additional information all redox-active metal centers are contained in subunits I and II eukaryota

Organism

Organism UniProt Comment Textmining
Bacteria
-
-
-
eukaryota
-
-
-
Mammalia
-
-
-
Paracoccus denitrificans
-
-
-

Reaction

Reaction Comment Organism Reaction ID
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O mechanism of O2 reduction Bacteria
a
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O mechanism of O2 reduction eukaryota
a
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O proposal for complete turnover cycle, i.e. intramolecular electron transfer, O2 reduction and proton pumping Bacteria
a
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O proposal for complete turnover cycle, i.e. intramolecular electron transfer, O2 reduction and proton pumping eukaryota
a
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O mechanism of proton pumping Mammalia
a
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O mechanism of proton pumping Bacteria
a
4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O mechanism of proton pumping eukaryota
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferrocytochrome c + O2
-
 Paracoccus denitrificans ferricytochrome c + H2O
-
 ?
ferrocytochrome c + O2 proton translocation across eukaryotic mitochondrial and prokyryotic cytoplasmic membrane, overview proposed mechanims Bacteria ferricytochrome c + H2O
-
 ?
ferrocytochrome c + O2 proton translocation across eukaryotic mitochondrial and prokyryotic cytoplasmic membrane, overview proposed mechanims eukaryota ferricytochrome c + H2O
-
 ?
ferrocytochrome c + O2 + H+
-
 Bacteria ferricytochrome c + H2O
-
 r
ferrocytochrome c + O2 + H+
-
 eukaryota ferricytochrome c + H2O
-
 r

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
30 600 ferrocytochrome c
-
 Bacteria
30 600 ferrocytochrome c
-
 eukaryota

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
 redox potential of cytochrome a is pH dependent eukaryota

Cofactor

Cofactor Comment Organism Structure
heme a
-
 Paracoccus denitrificans
heme a
-
 Mammalia
heme a located in subunit I Bacteria
heme a located in subunit I eukaryota
Heme a3
-
 Mammalia
Heme a3 located in subunit I Paracoccus denitrificans
Heme a3 located in subunit I Bacteria
Heme a3 located in subunit I eukaryota