Literature summary for 7.1.1.8 extracted from

Schaegger, H.; Brandt, U.; Gencic, S.; von Jagow, G.
Ubiquinol-cytochrome-c reductase from human and bovine mitochondria (1995), Methods Enzymol., 260, 82-96.

Activating Compound

Activating Compound	Comment	Organism	Structure
dodecyl maltoside	-	Bos taurus

Inhibitors

Inhibitors	Comment	Organism	Structure
hydroxyapatite	-	Bos taurus
Stigmatellin	-	Bos taurus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Saccharomyces cerevisiae	16020	-
membrane	membrane-bound	Homo sapiens	16020	-
membrane	membrane-bound	Bos taurus	16020	-
mitochondrion	-	Saccharomyces cerevisiae	5739	-
mitochondrion	-	Bos taurus	5739	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
6400	-	ISP-associated protein, SDS-PAGE	Bos taurus
6519	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
7200	-	cytochrome c1-associated protein, SDS-PAGE	Bos taurus
7326	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
7955	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
8000	-	-	Bos taurus
8000	-	subunit IX, SDS-PAGE	Homo sapiens
8053	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
9174	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
9261	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
9588	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
13345	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
13380	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
21608	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
21630	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
27285	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
27350	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
42588	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
42727	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
46520	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
46808	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
47000	-	core protein I, SDS-PAGE	Bos taurus
48960	-	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
49200	-	core protein I, amino acid sequence	Bos taurus
49209	-	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus
241100	-	total mass of protein moiety	Bos taurus
243300	-	complete enzyme monomer, amino acid composition	Bos taurus
500000	-	analytical ultracentrifugation	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-
Homo sapiens	-	human	-
Saccharomyces cerevisiae	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
heart	-	Homo sapiens	-
heart	-	Bos taurus	-
liver	-	Homo sapiens	-
liver	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.
ubiquinol + 2 ferricytochrome c	-	Homo sapiens	ubiquinone + 2 ferrocytochrome c + 2 H+	-	?
ubiquinol + 2 ferricytochrome c	-	Saccharomyces cerevisiae	ubiquinone + 2 ferrocytochrome c + 2 H+	-	?
ubiquinol + 2 ferricytochrome c	-	Bos taurus	ubiquinone + 2 ferrocytochrome c + 2 H+	-	?

Subunits

Subunits	Comment	Organism
dimer	-	Bos taurus
octamer	-	Saccharomyces cerevisiae
octamer	-	Bos taurus
octamer	1 * 48960 + 1 * 46808 + 1 * 42727 + 1 * 27350 + 1 * 21630 + 1 * 13380 + 1 * 9261 + 1 * 8053, calculated from the amino acid sequence of the mature protein	Homo sapiens
undecamer	1 * 49209 + 1 * 46520 + 1 * 42588 + 1 * 27285 + 1 * 21608 + 1 * 13345 + 1 * 9588 + 1 * 9174 + 1 * 7955 + 1 * 7326 + 1 * 6519, core protein I, core protein II, cytochrome b, cytochrome c1, iron-sulfur protein, cytochrome b-associated protein, core associated protein, hinge protein, ISP targeting peptide, cytochrome c1-associated protein, ISP-associated protein, calculated from amino acid sequence of the mature protein	Bos taurus