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Literature summary for 7.1.1.5 extracted from

  • Lemma, E.; Simon, J.; Schagger, H.; Kroger, A.
    Properties of the menaquinol oxidase (Qox) and of qox deletion mutants of Bacillus subtilis (1995), Arch. Microbiol., 163, 432-438.
    View publication on PubMed
Search for more literature for 7.1.1.5

Inhibitors

Inhibitors Comment Organism Structure
2-(n-heptyl)-4-hydroxyquinoline-N-oxide
-
 Bacillus subtilis
antimycin A more than 10fold less effective than 2-(n-heptyl)-4-hydroxyquinoline-N-oxide, 39% residual activity at 0.01 mM Bacillus subtilis
cyanide 47% residual activity at 0.5 mM Bacillus subtilis
Myxothiazol more than 10fold less effective than 2-(n-heptyl)-4-hydroxyquinoline-N-oxide, 45% residual activity at 0.01 mM Bacillus subtilis
Stigmatellin more than 10fold less effective than 2-(n-heptyl)-4-hydroxyquinoline-N-oxide, 39% residual activity at 0.01 mM Bacillus subtilis

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Bacillus subtilis 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
13686
-
 1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
15000
-
 1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
20000
-
 1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
22670
-
 1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
33640
-
 1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
36000
-
 1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
54000
-
 1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis
73834
-
 1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
144000
-
 calculated from sequence of cDNA Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
menaquinol + O2 Bacillus subtilis
-
 menaquinone + H2O
-
 ?
menaquinol + O2 Bacillus subtilis W23
-
 menaquinone + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-
Bacillus subtilis W23
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture condition:glucose-grown cell
-
 Bacillus subtilis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 2,3-dimethyl-1,4-naphthoquinol + O2 + n H+[side 1] best substrate Bacillus subtilis 2 2,3-dimethyl-1,4-naphthoquinone + 2 H2O + n H+[side 2]
-
 ?
2 2,3-dimethyl-1,4-naphthoquinol + O2 + n H+[side 1] best substrate Bacillus subtilis W23 2 2,3-dimethyl-1,4-naphthoquinone + 2 H2O + n H+[side 2]
-
 ?
menadiol + O2 + n H+[side 1]
-
 Bacillus subtilis menadione + H2O + n H+[side 2]
-
 ?
menadiol + O2 + n H+[side 1]
-
 Bacillus subtilis W23 menadione + H2O + n H+[side 2]
-
 ?
menaquinol + O2
-
 Bacillus subtilis menaquinone + H2O
-
 ?
menaquinol + O2
-
 Bacillus subtilis W23 menaquinone + H2O
-
 ?
additional information no activity with 1,4-naphthoquinol, N,N,N',N'-tetramethyl-1,4-phenylenediamine plus ascorbate or reduced cytochrome c Bacillus subtilis ?
-
 ?
additional information no activity with 1,4-naphthoquinol, N,N,N',N'-tetramethyl-1,4-phenylenediamine plus ascorbate or reduced cytochrome c Bacillus subtilis W23 ?
-
 ?

Subunits

Subunits Comment Organism
heterotetramer 1 * 33640 + 1 * 73834 + 1 * 22670 + 1 * 13686, subunits QoxA, QoxB, QoxC and QoxD, calculated from sequence of cDNA Bacillus subtilis
heterotetramer 1 * 36000 + 1 * 54000 + 1 * 20000 + 1 * 15000, subunits QoxA, QoxB, QoxC and QoxD, SDS-PAGE Bacillus subtilis

Synonyms

Synonyms Comment Organism
menaquinol oxidase (aa3-600)
-
 Bacillus subtilis
Qox
-
 Bacillus subtilis

Cofactor

Cofactor Comment Organism Structure
cytochrome the enzyme contains 7 mol cytochrome aa 3 per g protein which corresponds to 2 mol heme A per mol enzyme Bacillus subtilis