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Literature summary for 7.1.1.2 extracted from

  • Deris, Z.Z.; Akter, J.; Sivanesan, S.; Roberts, K.D.; Thompson, P.E.; Nation, R.L.; Li, J.; Velkov, T.
    A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity (2014), J. Antibiot., 67, 147-151 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
colistin
-
 Acinetobacter baumannii
colistin
-
 Escherichia coli
colistin
-
 Klebsiella pneumoniae
Polymyxin B
-
 Acinetobacter baumannii
Polymyxin B mixed inhibition with respect to ubiquinone-1 and non-competitive inhibition with respect to NADH Escherichia coli
Polymyxin B
-
 Klebsiella pneumoniae
polymyxin B1
-
 Escherichia coli
polymyxin B2
-
 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Escherichia coli 16020
-
membrane
-
 Klebsiella pneumoniae 16020
-
membrane
-
 Acinetobacter baumannii 16020
-

Organism

Organism UniProt Comment Textmining
Acinetobacter baumannii
-
-
-
Acinetobacter baumannii ATCC 19606
-
-
-
Escherichia coli
-
-
-
Escherichia coli DH5alpha
-
-
-
Klebsiella pneumoniae
-
-
-
Klebsiella pneumoniae ATCC 13883
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone-1 + 5 H+[side 1]
-
 Escherichia coli NAD+ + ubiquinol-1 + 4 H+[side 2]
-
 ?
NADH + ubiquinone-1 + 5 H+[side 1]
-
 Escherichia coli DH5alpha NAD+ + ubiquinol-1 + 4 H+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
NDH-2
-
 Escherichia coli
NDH-2
-
 Klebsiella pneumoniae
NDH-2
-
 Acinetobacter baumannii

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.045
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli polymyxin B1
0.05
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli Polymyxin B
0.057
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli polymyxin B2
0.167
-
 pH not specified in the publication, temperature not specified in the publication Acinetobacter baumannii Polymyxin B
0.168
-
 pH not specified in the publication, temperature not specified in the publication Klebsiella pneumoniae Polymyxin B
0.251
-
 pH not specified in the publication, temperature not specified in the publication Escherichia coli colistin
0.356
-
 pH not specified in the publication, temperature not specified in the publication Acinetobacter baumannii colistin
0.376
-
 pH not specified in the publication, temperature not specified in the publication Klebsiella pneumoniae colistin