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Literature summary for 7.1.1.2 extracted from

  • Bazil, J.N.; Pannala, V.R.; Dash, R.K.; Beard, D.A.
    Determining the origins of superoxide and hydrogen peroxide in the mammalian NADH ubiquinone oxidoreductase (2014), Free Radic. Biol. Med., 77, 121-129 .
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mammalia
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information computational model of mammalian complex I for catalysis. The fully reduced FMN and semiquinone are the primary sources of superoxide, and the iron-sulfur cluster N2 produces none. The FMN radical only produces reactive oxygen species when the quinone reductase site is blocked. Reaxtive oxygen species generation is maximized during reverse electron transport with both the FMN and semiquinone producing similar amounts of superoxide. The model successfully predicts the increase in reactive oxygen species generation when the membrane potential is high and matrix pH is alkaline Mammalia ?
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