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Literature summary for 7.1.1.2 extracted from

  • Grivennikova, V.G.; Gladyshev, G.V.; Vinogradov, A.D.
    Allosteric nucleotide-binding site in the mitochondrial NADH:ubiquinone oxidoreductase (respiratory complex I) (2011), FEBS Lett., 585, 2212-2216.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.2

Activating Compound

Activating Compound Comment Organism Structure
ADP 4.5fold activation of NADH:ubiquinone oxidoreductase at 0.1 M Bos taurus
ATP 10fold activation of NADH:ubiquinone oxidoreductase at 0.1 M, ATP in the micromolar concentration range specifically stimulates the NADH:hexaammineruthenium(III) (HAR) reductase activity catalyzed by eukaryotic complex I when assayed at low NADH and acceptor concentrations Bos taurus
ATP ATP in the micromolar concentration range specifically stimulates the NADH:hexaammineruthenium(III) (HAR) reductase activity catalyzed by eukaryotic complex I when assayed at low NADH and acceptor concentrations Yarrowia lipolytica
additional information no activation by adenylylimidodiphosphate, GTP, GDP, adenosine, AMP, cAMP, and CTP Bos taurus
additional information no stimulation of the three-subunit FP fragment of complex I or for membrane-bound NDH-1 by ATP Paracoccus denitrificans

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion submitochondrial fragments Bos taurus 5739
-
mitochondrion submitochondrial fragments Yarrowia lipolytica 5739
-
plasma membrane
-
 Paracoccus denitrificans 5886
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Paracoccus denitrificans
-
-
-
Yarrowia lipolytica
-
 var. alkalitolerance
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity Bos taurus ?
-
 ?
additional information the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity Yarrowia lipolytica ?
-
 ?
additional information the enzyme shows also rotenone-insensitive NADH:hexaammineruthenium III (HAR) oxidoreductase activity. The enzyme NDH-1 catalyzes a number of the NADH:artificial electron acceptor oxidoreductase activities showing particularly high turnover numbers with ferricyanide and hexaammineruthenium(III), kinetic patterns of the steady-state NADH oxidation with these two electron acceptors, overview Paracoccus denitrificans ?
-
 ?

Synonyms

Synonyms Comment Organism
mitochondrial NADH:ubiquinone oxidoreductase
-
 Bos taurus
mitochondrial NADH:ubiquinone oxidoreductase
-
 Yarrowia lipolytica
NADH:HAR reductase
-
 Paracoccus denitrificans
NADH:HAR reductase
-
 Bos taurus
NADH:HAR reductase
-
 Yarrowia lipolytica
NDH-1 prokaryotic complex I homolog Paracoccus denitrificans
respiratory complex I
-
 Bos taurus
respiratory complex I
-
 Yarrowia lipolytica

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Paracoccus denitrificans
30
-
 assay at Bos taurus
30
-
 assay at Yarrowia lipolytica

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Paracoccus denitrificans
8
-
 assay at Bos taurus
8
-
 assay at Yarrowia lipolytica

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Paracoccus denitrificans
NADH
-
 Bos taurus
NADH
-
 Yarrowia lipolytica

General Information

General Information Comment Organism
additional information the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site Paracoccus denitrificans
additional information the accessory subunits of eukaryotic complex I bear an allosteric ATP binding site Yarrowia lipolytica
additional information the accessory’ subunits of eukaryotic complex I bear an allosteric ATP binding site Bos taurus