Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrial inner membrane | - |
Bos taurus | 5743 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + ubiquinone + 6 H+[side 1] | Bos taurus | - |
NAD+ + ubiquinol + 7 H+[side 2] | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
NADH + ubiquinone + 6 H+[side 1] = NAD+ + ubiquinol + 7 H+[side 2] | tri-bi enzyme mechanism combined with a simple model of the conformational changes associated with proton transport, hybrid ping-pong rapid-equilibrium random bi-bi catalytic mechanism, kinetic mechanism and general kinetic model for conformational change in a tri-bi enzyme mechanism, overview | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + ubiquinone + 6 H+[side 1] | - |
Bos taurus | NAD+ + ubiquinol + 7 H+[side 2] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
complex I | - |
Bos taurus |
NADH-ubiquinone oxidoreductase | - |
Bos taurus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Bos taurus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
9 | - |
assay at | Bos taurus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | activity range | Bos taurus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Bos taurus |
General Information | Comment | Organism |
---|---|---|
evolution | complex I has been subject to a phenomenal increase in size that predates the diversification of extant eukaryotes, followed by very few lineage-specific additions/losses of subunits | Bos taurus |
physiological function | complex I is one of the respiratory complexes that generate the proton-motive force required for the synthesis of ATP in mitochondria. The electron transfer from NADH to ubiquinone through protein-bound prosthetic groups, which is coupled to the translocation of protons across the inner mitochondrial membrane | Bos taurus |