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Literature summary for 7.1.1.2 extracted from

  • Miller, J.L.; Velmurugan, K.; Cowan, M.J.; Briken, V.
    The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis (2010), PLoS Pathog., 6, e1000864.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
3-azido-ubiquinone-2
-
 Mycobacterium tuberculosis
6-amino-4-(4-tert-butylphenethylamino)quinazoline
-
 Mycobacterium tuberculosis
6-azido-4-(4-iodophenethylamino)quinazoline the compound specifically binds to the 49000 Da and ND1 subunits with a frequency of about 4:1 Mycobacterium tuberculosis
bullatacin
-
 Mycobacterium tuberculosis
fenpyroximate
-
 Mycobacterium tuberculosis
Piericidin A
-
 Mycobacterium tuberculosis
pyridabene
-
 Mycobacterium tuberculosis
rotenone
-
 Mycobacterium tuberculosis

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37RV (ATCC 25618)
-
-
-

Synonyms

Synonyms Comment Organism
NDH-1 the NuoG subunit of the type I NADH dehydrogenase Mycobacterium tuberculosis
type I NADH dehydrogenase
-
 Mycobacterium tuberculosis

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Mycobacterium tuberculosis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000045
-
 pH and temperature not specified in the publication Mycobacterium tuberculosis 6-amino-4-(4-tert-butylphenethylamino)quinazoline

General Information

General Information Comment Organism
physiological function the NuoG subunit of the type I NADH dehydrogenase, NDH-1, is important in Mycobacterium tuberculosis-mediated inhibition of host macrophage apoptosis, the NDH-1 complex is important for NOX2 neutralization in host macrophages Mycobacterium tuberculosis