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Literature summary for 7.1.1.2 extracted from

  • Koopman, W.J.; Verkaart, S.; van Emst-de Vries, S.E.; Grefte, S.; Smeitink, J.A.; Nijtmans, L.G.; Willems, P.H.
    Mitigation of NADH:ubiquinone oxidoreductase deficiency by chronic Trolox treatment (2008), Biochim. Biophys. Acta, 1777, 853-859.
    View publication on PubMed

Application

Application Comment Organism
medicine cellular levels of reactive oxygen species are significantly increased in cells of patients with DNA-inherited isolated complex I deficiency. This increase is associated with variable decreases in the amount and intrinsic catalytic activity of complex I. Chronic treatment with a vitamin E derivative (Trolox) increases the amount of complex I and might provide an experimental basis for the use of antioxidants to treat complex I deficient patients Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin fibroblast
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Homo sapiens
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Synonyms

Synonyms Comment Organism
NADH:ubiquinone oxidoreductase
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Homo sapiens