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Literature summary for 7.1.1.2 extracted from

  • Lund, K.C.; Wallace, K.B.
    Adenosine 3,5-cyclic monophosphate (cAMP)-dependent phosphoregulation of mitochondrial complex I is inhibited by nucleoside reverse transcriptase inhibitors (2008), Toxicol. Appl. Pharmacol., 226, 94-106.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.2

Application

Application Comment Organism
drug development nucleoside analog reverse transcriptase inhibitors are capable of affecting complex I activity in a non-polymerase-gamma/mtDNA mediated pathway. Elevations in superoxide produced at complex I caused by nucleoside analog reverse transcriptase inhibitors can provide a mechanism for the oxidative stress observed with these drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2',3'-dideoxycytidine 0.001 mM prevents the phosphorylation of the NDUFB11 subunit of complex I Homo sapiens
3'-azido-3'-deoxythymidine 0.01 and 0.05 mM prevent the phosphorylation of the NDUFB11 subunit of complex I. This is associated with a decrease in complex I activity Homo sapiens
3'-azido-3'-deoxythymidine monophosphate 0.15 mM prevents the phosphorylation of the NDUFB11 subunit of complex I. This is associated with a decrease in complex I activity Homo sapiens
rotenone
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
immunocapture-purified Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
complex I
-
 Homo sapiens
NADH:CoQ1 oxidoreductase
-
 Homo sapiens