Application | Comment | Organism |
---|---|---|
medicine | correlation between peripheral complex I activity and cerebral glucose metabolism in regions implicated in schizophrenia, may be a pathological factor that is differentially expressed in subgroups of schizophrenic patients | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
basal ganglion | in the high positive schizophrenic group a positive correlation exists between cerebral glucose metabolism and complex I activity in the basal ganglia (lentiform nucleus including the putamen and globus pallidus) and the thalamus, but reaches significance only for its left side | Homo sapiens | - |
blood platelet | complex I activity is significantly higher in high positive schizophrenics as compared to control subjects and low positive schizophrenic patients. In low positive schizophrenic patients complex I activity does not differ from that of the control group. Entering age and gender as covariates has no effect on the significance of difference in complex I activity between subject groups. Significant positive correlation between complex I activity and the severity of positive symptoms | Homo sapiens | - |
brain stem | in the low positive schizophrenic group, a region of negative correlation between cerebral glucose metabolism and complex I activity is identified bilaterally in the cerebellum and brainstem | Homo sapiens | - |
cerebellum | in the low positive schizophrenic group, a region of negative correlation between cerebral glucose metabolism and complex I activity is identified bilaterally in the cerebellum and brainstem | Homo sapiens | - |
additional information | in the control group, no areas of significant positive or negative correlation between cerebral glucose metabolism and peripheral complex I activity exist | Homo sapiens | - |
thalamus | in the high positive schizophrenic group a positive correlation exists between cerebral glucose metabolism and complex I activity in the basal ganglia (lentiform nucleus including the putamen and globus pallidus) and the thalamus, but reaches significance only for its left side | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
complex I | - |
Homo sapiens |
NADH CoQ reductase | - |
Homo sapiens |