Application | Comment | Organism |
---|---|---|
additional information | an assembled complex IV helps to maintain complex I in mammalian cells | Mus musculus |
additional information | an assembled complex IV helps to maintain complex I in mammalian cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | COX I mutant cybrids show a 80% reduction in complex I enzymatic activity in isolated mitochondria as compared with control cybrids | Homo sapiens | |
additional information | mouse cell lines with suppressed expression of the nuclearly encoded subunit 4 of complex IV associated with a loss of assembly of complex IV show significantly reduced level of assembled complex I and activity, whereas levels and activity of complex III are normal or up-regulated | Mus musculus | |
rotenone | completely obstructs electron transfer through complex I | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-9 cell | - |
Mus musculus | - |
additional information | transmitochondrial cell line, cybrids from a patient with a multisystem mitochondrial disorder with a G6930A nonsense mutation in the COX I gene. G6930A mutation causes a disruption in the assembly and defective activity of complex VI | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ubiquinone + NADH + H+ | - |
Mus musculus | ubiquinol + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
complex I | - |
Mus musculus |
complex I | - |
Homo sapiens |
NADH-ubiquinone oxidoreductase | - |
Mus musculus |
NADH-ubiquinone oxidoreductase | - |
Homo sapiens |