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Literature summary for 7.1.1.2 extracted from

  • Coe, K.J.; Jia, Y.; Ho, H.K.; Rademacher, P.; Bammler, T.K.; Beyer, R.P.; Farin, F.M.; Woodke, L.; Plymate, S.R.; Fausto, N.; Nelson, S.D.
    Comparison of the cytotoxicity of the nitroaromatic drug flutamide to its cyano analogue in the hepatocyte cell line TAMH: evidence for complex I inhibition and mitochondrial dysfunction using toxicogenomic screening (2007), Chem. Res. Toxicol., 20, 1277-1290.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
flutamide inhibits complex I of the electron transport chain to a greater extent than a nitro to cyano analogue of flutamide. As compared to the nitro to cyano analogue of flutamide, the nitroaromatic group of flutamide enhances cytotoxicity to hepatocytes, likely through mechanisms involving mitochondrial dysfunction and ATP depletion that include complex I inhibition Mus musculus
rotenone is a more potent inhibitor of complex I than flutamide. Inhibits complex I of the electron transport chain to a greater extent than a nitro to cyano analogue of flutamide Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
TAMH cell TGFalpha-transfected mouse hepatocyte cell line Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
decyl-ubiquinone + NADH + H+
-
 Mus musculus decyl-ubiquinol + NAD+
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Mus musculus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.15
-
-
 Mus musculus flutamide