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Literature summary for 7.1.1.2 extracted from

  • Lambert, A.J.; Buckingham, J.A.; Boysen, H.M.; Brand, M.D.
    Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport (2008), Biochim. Biophys. Acta, 1777, 397-403.
    View publication on PubMed
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
diphenyleneiodonium strongly inhibits superoxide production by complex I driven by reverse electron transport from succinate. Inhibition of superoxide production is not dependent on changes in the pH gradient. The inhibitor does not react with the flavin of complex I Rattus norvegicus
Myxothiazol complex I Q-reduction site inhibitor Rattus norvegicus
piericidin complex I Q-reduction site inhibitor Rattus norvegicus
rotenone strongly inhibits superoxide production by complex I Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
malate + pyruvate + O2
-
 Rattus norvegicus ?
-
 ?
succinate + O2 + NAD+
-
 Rattus norvegicus NADH + ?
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
flavin
-
 Rattus norvegicus