Literature summary for 7.1.1.2 extracted from

Koopman, W.J.; Hink, M.A.; Verkaart, S.; Visch, H.J.; Smeitink, J.A.; Willems, P.H.
Partial complex I inhibition decreases mitochondrial motility and increases matrix protein diffusion as revealed by fluorescence correlation spectroscopy (2007), Biochim. Biophys. Acta, 1767, 940-947.

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Application

Application	Comment	Organism
additional information	reduction in complex I activity results in a decrease in mitochondrial movement which is compensated for by an increase in mitochondrial length and degree of branching and an enhanced diffusion of matrix constituents	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
rotenone	when complex I activity is chronically reduced by 80% using 100 nanomol rotenone, the percentage of moving mitochondria decreases from 79% to 50% and reduce their velocity by 30%	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skin fibroblast	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
complex I	-	Homo sapiens

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Release 2023.1 (January 2023)