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Literature summary for 7.1.1.2 extracted from

  • Grad, L.I.; Lemire, B.D.
    Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants (2006), Biochim. Biophys. Acta, 1757, 115-122.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
riboflavin 0.001 mg/ml Caenorhabditis elegans

Protein Variants

Protein Variants Comment Organism
A352V mutation in the 51 kDa subunit, shows mildly decreased NADH-dependent respiration and lactic acidosis Caenorhabditis elegans
A443F mutation in the 51 kDa subunit, shows decreased NADH-dependent respiration and lactic acidosis Caenorhabditis elegans
T434M mutation in the 51 kDa subunit, shows decreased NADH-dependent respiration and lactic acidosis Caenorhabditis elegans

Inhibitors

Inhibitors Comment Organism Structure
rotenone 0.002 mg/ml Caenorhabditis elegans

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Caenorhabditis elegans 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
51000
-
nuo-I subunit of wild type enzyme, SDS-PAGE Caenorhabditis elegans
950000
-
whole wild type enzyme, SDS-PAGE Caenorhabditis elegans

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + 2,3-dimethoxy-5-methyl-6-[(6-methyl-2,3-dihydroimidazo[2,1-b][1,3]thiazol-5-yl)methyl]benzo-1,4-quinone
-
Caenorhabditis elegans NAD+ + ?
-
?

Synonyms

Synonyms Comment Organism
complex I
-
Caenorhabditis elegans
NADH-ubiquinone oxidoreductase
-
Caenorhabditis elegans

Cofactor

Cofactor Comment Organism Structure
NADH
-
Caenorhabditis elegans