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Literature summary for 7.1.1.2 extracted from

  • Kao, M.C.; Nakamaru-Ogiso, E.; Matsuno-Yagi, A.; Yagi, T.
    Characterization of the membrane domain subunit NuoK (ND4L) of the NADH-quinone oxidoreductase from Escherichia coli (2005), Biochemistry, 44, 9545-9554.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
E36A almost no NDH-1 activity Escherichia coli
E36Q almost no NDH-1 activity Escherichia coli
E72A NDH-1 activity similar to wild type enzyme Escherichia coli
E72Q NDH-1 activity similar to wild type enzyme Escherichia coli
F15A NDH-1 activity similar to wild type enzyme Escherichia coli
G21V reduced NDH-1 activity Escherichia coli
R25A reduced NDH-1 activity Escherichia coli
R25A/R26A strongly reduced NDH-1 activity Escherichia coli
R25K reduced NDH-1 activity Escherichia coli
R26A reduced NDH-1 activity Escherichia coli
R26K NDH-1 activity similar to wild type enzyme Escherichia coli
R85A NDH-1 activity similar to wild type enzyme Escherichia coli
R85K NDH-1 activity similar to wild type enzyme Escherichia coli
R87A NDH-1 activity similar to wild type enzyme Escherichia coli
R87K NDH-1 activity similar to wild type enzyme Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
capsaicin-40 0.01 mM Escherichia coli
N,N'-dicyclohexylcarbodiimide 2 mM, 71% inhibition Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Escherichia coli 16020
-

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.04
-
mutant enzyme E36A, using deamino-NADH as electron donor Escherichia coli
0.042
-
mutant enzyme E36Q, using deamino-NADH as electron donor Escherichia coli
0.08
-
mutant enzyme R25A/R26A, using deamino-NADH as electron donor Escherichia coli
0.149
-
mutant enzyme E72Q, using deamino-NADH as electron donor Escherichia coli
0.151
-
mutant enzyme R25A, using deamino-NADH as electron donor Escherichia coli
0.176
-
mutant enzyme R25K, using deamino-NADH as electron donor Escherichia coli
0.222
-
mutant enzyme R26A, using deamino-NADH as electron donor Escherichia coli
0.273
-
mutant enzyme E72A, using deamino-NADH as electron donor Escherichia coli
0.351
-
mutant enzyme G21V, using deamino-NADH as electron donor Escherichia coli
0.514
-
mutant enzyme F15A, using deamino-NADH as electron donor Escherichia coli
0.556
-
mutant enzyme R85K, using deamino-NADH as electron donor Escherichia coli
0.564
-
mutant enzyme R85A, using deamino-NADH as electron donor Escherichia coli
0.568
-
mutant enzyme R87A, using deamino-NADH as electron donor Escherichia coli
0.571
-
wild type enzyme, using deamino-NADH as electron donor Escherichia coli
0.603
-
mutant enzyme R87K, using deamino-NADH as electron donor Escherichia coli
0.62
-
mutant enzyme R26K, using deamino-NADH as electron donor Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deamino-NADH + dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
-
Escherichia coli deamino-NAD+ + reduced dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
-
?

Subunits

Subunits Comment Organism
More NuoK is the smallest subunit of Escherichia coli NDH-1 Escherichia coli

Synonyms

Synonyms Comment Organism
complex I
-
Escherichia coli
NADH-quinone oxidoreductase
-
Escherichia coli
NDH-1
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
deamino-NADH
-
Escherichia coli
NADH
-
Escherichia coli