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Literature summary for 7.1.1.2 extracted from

  • Lambert, A.J.; Brand, M.D.
    Inhibitors of the quinone-binding site allow rapid superoxide production from mitochondrial NADH:ubiquinone oxidoreductase (complex I) (2004), J. Biol. Chem., 279, 39414-39420.
    View publication on PubMed
Search for more literature for 7.1.1.2

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Rattus norvegicus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus superoxide production rates by complex I during reverse electron transfer are much greater than during forwards electron transfer. The major site of superoxide production in complex I is the quinpone-binding site, it is most likely a semiquinone ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information superoxide production rates by complex I during reverse electron transfer are much greater than during forwards electron transfer. The major site of superoxide production in complex I is the quinpone-binding site, it is most likely a semiquinone Rattus norvegicus ?
-
 ?
NADH + coenzyme Q2
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 Rattus norvegicus NAD+ + ?
-
 ?

Synonyms

Synonyms Comment Organism
complex I
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 Rattus norvegicus
NADH:ubiquinone oxidoreductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Rattus norvegicus