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Literature summary for 6.5.1.8 extracted from

  • Kosmaczewski, S.; Han, S.; Han, B.; Meyer, B.; Baig, H.; Athar, W.; Lin-Moore, A.; Koelle, M.; Hammarlund, M.
    RNA ligation in neurons by RtcB inhibits axon regeneration (2015), Proc. Natl. Acad. Sci. USA, 112, 8451-8456 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.8

Activating Compound

Activating Compound Comment Organism Structure
archease
-
 Caenorhabditis elegans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O Caenorhabditis elegans
-
 (ribonucleotide)n+m + GMP + diphosphate
-
 ?
(ribonucleotide)n-3'-phosphate + 5'-hydroxy-(ribonucleotide)m + GTP Caenorhabditis elegans
-
 (ribonucleotide)n+m + GMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Caenorhabditis elegans
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
neuron
-
 Caenorhabditis elegans
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(ribonucleotide)n-2',3'-cyclophosphate + 5'-hydroxy-(ribonucleotide)m + GTP + H2O
-
 Caenorhabditis elegans (ribonucleotide)n+m + GMP + diphosphate
-
 ?
(ribonucleotide)n-3'-phosphate + 5'-hydroxy-(ribonucleotide)m + GTP
-
 Caenorhabditis elegans (ribonucleotide)n+m + GMP + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
rtcB
-
 Caenorhabditis elegans

Expression

Organism Comment Expression
Caenorhabditis elegans the enzyme is enriched at axon termini after nerve injury up

General Information

General Information Comment Organism
physiological function the enzyme is a critical regulator of neuronal growth potential and inhibits axon regeneration Caenorhabditis elegans