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Literature summary for 6.5.1.8 extracted from

  • Lu, Y.; Liang, F.X.; Wang, X.
    A synthetic biology approach identifies the mammalian UPR RNA ligase RtcB (2014), Mol. Cell, 55, 758-770.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.8

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum a subset of RtcB is associated with the endoplasmic reticulum Mus musculus 5783
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nuclear envelope a subset of RtcB is associated with the nuclear envelope Mus musculus 5635
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Organism

Organism UniProt Comment Textmining
Mus musculus Q99LF4
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General Information

General Information Comment Organism
physiological function RtcB as the primary unfolded protein response RNA ligase. In RtcB knockout cells, unconventional XBP1 mRNA splicing is defective during ER stress. The RNA ligase activity of RtcB is directly required for the splicing of XBP1 mRNA Mus musculus