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Literature summary for 6.5.1.3 extracted from

  • Wang, L.K.; Schwer, B.; Englert, M.; Beier, H.; Shuman, S.
    Structure-function analysis of the kinase-CPD domain of yeast tRNA ligase (Trl1) and requirements for complementation of tRNA splicing by a plant Trl1 homolog (2006), Nucleic Acids Res., 34, 517-527.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.3

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
D425N lethal mutation Saccharomyces cerevisiae
D726A lethal mutation Saccharomyces cerevisiae
E218A lethal mutation Saccharomyces cerevisiae
E326A lethal mutation Saccharomyces cerevisiae
E741A lethal mutation Saccharomyces cerevisiae
H1060A lethal mutation Saccharomyces cerevisiae
H515A lethal mutation Saccharomyces cerevisiae
H515N lethal mutation Saccharomyces cerevisiae
H515Q lethal mutation Saccharomyces cerevisiae
H777N lethal mutation Saccharomyces cerevisiae
H777Q lethal mutation Saccharomyces cerevisiae
K152A lethal mutation Saccharomyces cerevisiae
K541A lethal mutation Saccharomyces cerevisiae
K543A lethal mutation Saccharomyces cerevisiae
R463A lethal mutation Saccharomyces cerevisiae
R463K lethal mutation Saccharomyces cerevisiae
R463Q lethal mutation Saccharomyces cerevisiae
R511K lethal mutation Saccharomyces cerevisiae
R511Q lethal mutation Saccharomyces cerevisiae
S701A lethal mutation Saccharomyces cerevisiae
T1001A lethal mutation Saccharomyces cerevisiae
T675A lethal mutation Saccharomyces cerevisiae
T675V lethal mutation Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (ribonucleotide)n + (ribonucleotide)m Saccharomyces cerevisiae Trl1 executes the end-healing and end-sealing steps of tRNA splicing, requires a 2'-PO4 end for tRNA splicing in vivo AMP + diphosphate + (ribonucleotide)n+m
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (ribonucleotide)n + (ribonucleotide)m Trl1 executes the end-healing and end-sealing steps of tRNA splicing, requires a 2'-PO4 end for tRNA splicing in vivo Saccharomyces cerevisiae AMP + diphosphate + (ribonucleotide)n+m
-
 ?

Synonyms

Synonyms Comment Organism
Trl1
-
 Saccharomyces cerevisiae