Literature summary for 6.5.1.3 extracted from

Sillero, M.A.; de Diego, A.; Silles, E.; Perez-Zuniga, F.; Sillero, A.
Synthesis of bisphosphonate derivatives of ATP by T4 RNA ligase (2006), FEBS Lett., 580, 5723-5727.

Search for more literature for 6.5.1.3

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.26	-	methylenebisphosphonate	-	Tequatrovirus T4
0.54	-	clodronate	-	Tequatrovirus T4
4.3	-	etidronate	-	Tequatrovirus T4

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + clodronate	-	Tequatrovirus T4	adenosine 5'-(beta,gamma-dichloromethylenetriphosphate) + ?	-	?
ATP + etidronate	weak activity	Tequatrovirus T4	?	-	?
ATP + methylenebisphosphonate	-	Tequatrovirus T4	adenosine 5'-(beta,gamma-methylenetriphosphate) + ?	-	?
additional information	no activity with alendronate nor pamidronate	Tequatrovirus T4	?	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.028	-	etidronate	-	Tequatrovirus T4
0.28	-	methylenebisphosphonate	-	Tequatrovirus T4
0.29	-	clodronate	-	Tequatrovirus T4

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Release 2023.1 (January 2023)