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Literature summary for 6.5.1.3 extracted from

  • Schnaufer, A.; Panigrahi, A.K.; Panicucci, B.; Igo, R.P., Jr.; Wirtz, E.; Salavati, R.; Stuart, K.
    An RNA ligase essential for RNA editing and survival of the bloodstream form of Trypanosoma brucei (2001), Science, 291, 2159-2162.
    View publication on PubMed

Application

Application Comment Organism
medicine regulated repression of the enzyme blocks editing, this repression is lethal in bloodforms of the parasite, indicating that editing is essential in the mammalian stage of the life cycle, the editing complex, which is present in all kinetoplastid parasites, may thus be a chemotherapeutic target Trypanosoma brucei

Cloned(Commentary)

Cloned (Comment) Organism
-
Trypanosoma brucei

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Trypanosoma brucei 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (ribonucleotide)n + (ribonucleotide)m Trypanosoma brucei RNA editing, essential for proliferation of Trypanosoma brucei AMP + diphosphate + (ribonucleotide)n+m
-
?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Purification (Commentary)

Purification (Comment) Organism
editing complex Trypanosoma brucei

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (ribonucleotide)n + (ribonucleotide)m
-
Trypanosoma brucei AMP + diphosphate + (ribonucleotide)n+m
-
?
ATP + (ribonucleotide)n + (ribonucleotide)m RNA editing, essential for proliferation of Trypanosoma brucei Trypanosoma brucei AMP + diphosphate + (ribonucleotide)n+m
-
?

Synonyms

Synonyms Comment Organism
TbMP52 macromolecular complex with RNA ligase activity Trypanosoma brucei