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Literature summary for 6.5.1.3 extracted from

  • Atencia, E.A.; Madrid, O.; Gunther Sillero, M.A.; Sillero, A.
    T4 RNA ligase catalyzes the synthesis of dinucleoside polyphosphates (1999), Eur. J. Biochem., 261, 802-811.
    View publication on PubMed
Search for more literature for 6.5.1.3

Inhibitors

Inhibitors Comment Organism Structure
tripolyphosphate
-
 Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (ribonucleotide)n + (ribonucleotide)m Tequatrovirus T4 catalyzes the transfer of AMP from the E-AMP complex to diverse compounds, generating the product indicated between parentheses, ATP(Ap4A), NTP (Ap4N), P3 or P4 (p4A or p5A), ADP (Ap3A) AMP + diphosphate + (ribonucleotide)n+m
-
 ?

Organism

Organism UniProt Comment Textmining
Tequatrovirus T4
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.06
-
-
 Tequatrovirus T4

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (ribonucleotide)n + (ribonucleotide)m
-
 Tequatrovirus T4 AMP + diphosphate + (ribonucleotide)n+m
-
 ?
ATP + (ribonucleotide)n + (ribonucleotide)m catalyzes the transfer of AMP from the E-AMP complex to diverse compounds, generating the product indicated between parentheses, ATP(Ap4A), NTP (Ap4N), P3 or P4 (p4A or p5A), ADP (Ap3A) Tequatrovirus T4 AMP + diphosphate + (ribonucleotide)n+m
-
 ?
ATP + ATP
-
 Tequatrovirus T4 P1,P4-bis(5'-adenosyl) tetraphosphate + diphosphate
-
 ?
ATP + ATP
-
 Tequatrovirus T4 P1,P3-bis(5'-adenosyl) triphosphate + ?
-
 ?
ATPgammaS + ATP
-
 Tequatrovirus T4 P1,P4-bis(5'-adenosyl) tetraphosphate + thiodiphosphate
-
 ?
GTP + ATP
-
 Tequatrovirus T4 P1-(5'-adenosyl),P4-(5'-guanosyl) tetraphosphate + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
T4 RNA ligase
-
 Tequatrovirus T4

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.017
-
 GTP pH 7.4, 37°C Tequatrovirus T4
0.055
-
 ATP pH 7.4, 30°C, ATP as acceptor of AMP, Ap4A synthesis Tequatrovirus T4

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
-
 Tequatrovirus T4

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8 around 70% of the maximum at pH 8.0 Tequatrovirus T4