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Literature summary for 6.5.1.2 extracted from

  • Murphy-Benenato, K.E.; Gingipalli, L.; Boriack-Sjodin, P.A.; Martinez-Botella, G.; Carcanague, D.; Eyermann, C.J.; Gowravaram, M.; Harang, J.; Hale, M.R.; Ioannidis, G.; Jahic, H.; Johnstone, M.; Kutschke, A.; Laganas, V.A.; Loch, J.T.; Miller, M.D.; Oguto, H.; Patel, S.J.
    Negishi cross-coupling enabled synthesis of novel NAD+-dependent DNA ligase inhibitors and SAR development (2015), Bioorg. Med. Chem. Lett., 25, 5172-5177 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
Escherichia coli
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
Haemophilus influenzae
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
Staphylococcus aureus
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
-
Streptococcus pneumoniae
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
Escherichia coli
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
Haemophilus influenzae
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
Staphylococcus aureus
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine
-
Streptococcus pneumoniae
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
Escherichia coli
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
Haemophilus influenzae
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
Staphylococcus aureus
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide
-
Streptococcus pneumoniae
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Escherichia coli
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Haemophilus influenzae
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Staphylococcus aureus
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
-
Streptococcus pneumoniae
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
Escherichia coli
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
Haemophilus influenzae
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
Staphylococcus aureus
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
-
Streptococcus pneumoniae
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
Escherichia coli
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
Haemophilus influenzae
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
Staphylococcus aureus
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
-
Streptococcus pneumoniae
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
Escherichia coli
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
Haemophilus influenzae
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
Staphylococcus aureus
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
-
Streptococcus pneumoniae
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
Escherichia coli
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
Haemophilus influenzae
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
Staphylococcus aureus
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
-
Streptococcus pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Staphylococcus aureus
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Haemophilus influenzae
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Streptococcus pneumoniae
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Haemophilus influenzae ARM158
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Escherichia coli ARC524
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Streptococcus pneumoniae ARC548
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m Staphylococcus aureus ARC561
-
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli ARC524
-
-
-
Haemophilus influenzae
-
-
-
Haemophilus influenzae ARM158
-
-
-
Staphylococcus aureus
-
-
-
Staphylococcus aureus ARC561
-
-
-
Streptococcus pneumoniae
-
-
-
Streptococcus pneumoniae ARC548
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Staphylococcus aureus (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Haemophilus influenzae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Escherichia coli (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Streptococcus pneumoniae (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Haemophilus influenzae ARM158 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Escherichia coli ARC524 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Streptococcus pneumoniae ARC548 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m
-
Staphylococcus aureus ARC561 (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide
-
?

Synonyms

Synonyms Comment Organism
LigA
-
Staphylococcus aureus
LigA
-
Haemophilus influenzae
LigA
-
Escherichia coli
LigA
-
Streptococcus pneumoniae
NAD+-dependent DNA ligase
-
Staphylococcus aureus
NAD+-dependent DNA ligase
-
Haemophilus influenzae
NAD+-dependent DNA ligase
-
Escherichia coli
NAD+-dependent DNA ligase
-
Streptococcus pneumoniae

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Staphylococcus aureus
NAD+
-
Haemophilus influenzae
NAD+
-
Escherichia coli
NAD+
-
Streptococcus pneumoniae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000007
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000013
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000015
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00002
-
at pH 7.4 and 20°C Streptococcus pneumoniae 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
0.00002
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00002
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00002
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00002
-
at pH 7.4 and 20°C Streptococcus pneumoniae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
0.000021
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000026
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00003
-
at pH 7.4 and 20°C Haemophilus influenzae 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
0.000031
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000032
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000034
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
0.000036
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000037
-
at pH 7.4 and 20°C Streptococcus pneumoniae 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
0.00004
-
at pH 7.4 and 20°C Staphylococcus aureus 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
0.000042
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000043
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000044
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000044
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000057
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000059
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000067
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000068
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.000077
-
at pH 7.4 and 20°C Staphylococcus aureus 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
0.000077
-
at pH 7.4 and 20°C Escherichia coli 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide
0.000084
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0001
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00011
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00011
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00011
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00012
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00012
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00012
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00012
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00015
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00015
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00016
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00016
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00017
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00022
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00022
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00023
-
at pH 7.4 and 20°C Escherichia coli 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
0.00026
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00027
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0003
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00031
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00031
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00034
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00035
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00039
-
at pH 7.4 and 20°C Streptococcus pneumoniae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
0.0004
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00041
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00042
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00043
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00046
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00047
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00047
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00049
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0005
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0005
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00052
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00052
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00053
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00053
-
at pH 7.4 and 20°C Staphylococcus aureus ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
0.00055
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00055
-
at pH 7.4 and 20°C Staphylococcus aureus 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
0.00059
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00062
-
at pH 7.4 and 20°C Haemophilus influenzae 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid
0.00064
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00065
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00067
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00069
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00072
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00072
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00074
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00078
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00079
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00081
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00097
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00101
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0011
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0011
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00133
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0014
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00144
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0015
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0016
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00165
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0017
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0018
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0018
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0018
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00209
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0021
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00219
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.00224
-
at pH 7.4 and 20°C Haemophilus influenzae 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile
0.00275
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0037
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.005
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.0066
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01
-
at pH 7.4 and 20°C Haemophilus influenzae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate
0.013
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.013
-
at pH 7.4 and 20°C Staphylococcus aureus 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.01398
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.044
-
at pH 7.4 and 20°C Streptococcus pneumoniae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.2
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.2
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.2
-
at pH 7.4 and 20°C Haemophilus influenzae 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile
0.2
-
at pH 7.4 and 20°C Staphylococcus aureus ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate
0.2
-
at pH 7.4 and 20°C Haemophilus influenzae ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate