Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | - |
Escherichia coli | |
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | - |
Haemophilus influenzae | |
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | - |
Staphylococcus aureus | |
2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | - |
Streptococcus pneumoniae | |
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine | - |
Escherichia coli | |
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine | - |
Haemophilus influenzae | |
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine | - |
Staphylococcus aureus | |
2-(cyclopentyloxy)-5'-deoxy-5'-fluoroadenosine | - |
Streptococcus pneumoniae | |
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide | - |
Escherichia coli | |
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide | - |
Haemophilus influenzae | |
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide | - |
Staphylococcus aureus | |
2-amino-5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxamide | - |
Streptococcus pneumoniae | |
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Escherichia coli | |
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Haemophilus influenzae | |
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Staphylococcus aureus | |
5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | - |
Streptococcus pneumoniae | |
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid | - |
Escherichia coli | |
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid | - |
Haemophilus influenzae | |
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid | - |
Staphylococcus aureus | |
5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid | - |
Streptococcus pneumoniae | |
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | - |
Escherichia coli | |
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | - |
Haemophilus influenzae | |
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | - |
Staphylococcus aureus | |
7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | - |
Streptococcus pneumoniae | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate | - |
Escherichia coli | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate | - |
Haemophilus influenzae | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate | - |
Staphylococcus aureus | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate | - |
Streptococcus pneumoniae | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate | - |
Escherichia coli | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate | - |
Haemophilus influenzae | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate | - |
Staphylococcus aureus | |
ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate | - |
Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Staphylococcus aureus | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Haemophilus influenzae | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Escherichia coli | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Streptococcus pneumoniae | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Haemophilus influenzae ARM158 | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Escherichia coli ARC524 | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Streptococcus pneumoniae ARC548 | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | Staphylococcus aureus ARC561 | - |
(deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Escherichia coli ARC524 | - |
- |
- |
Haemophilus influenzae | - |
- |
- |
Haemophilus influenzae ARM158 | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Staphylococcus aureus ARC561 | - |
- |
- |
Streptococcus pneumoniae | - |
- |
- |
Streptococcus pneumoniae ARC548 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Staphylococcus aureus | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Haemophilus influenzae | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Escherichia coli | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Streptococcus pneumoniae | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Haemophilus influenzae ARM158 | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Escherichia coli ARC524 | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Streptococcus pneumoniae ARC548 | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? | |
NAD+ + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m | - |
Staphylococcus aureus ARC561 | (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LigA | - |
Staphylococcus aureus |
LigA | - |
Haemophilus influenzae |
LigA | - |
Escherichia coli |
LigA | - |
Streptococcus pneumoniae |
NAD+-dependent DNA ligase | - |
Staphylococcus aureus |
NAD+-dependent DNA ligase | - |
Haemophilus influenzae |
NAD+-dependent DNA ligase | - |
Escherichia coli |
NAD+-dependent DNA ligase | - |
Streptococcus pneumoniae |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Staphylococcus aureus | |
NAD+ | - |
Haemophilus influenzae | |
NAD+ | - |
Escherichia coli | |
NAD+ | - |
Streptococcus pneumoniae |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000007 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000013 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000015 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00002 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | |
0.00002 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00002 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00002 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00002 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate | |
0.000021 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000026 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00003 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | |
0.000031 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000032 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000034 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid | |
0.000036 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000037 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | |
0.00004 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | |
0.000042 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000043 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000044 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000044 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000057 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000059 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000067 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000068 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(4-methyl-1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.000077 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | |
0.000077 | - |
at pH 7.4 and 20°C | Escherichia coli | 7-amino-2-tert-butyl-4-(1H-pyrrol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carboxamide | |
0.000084 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0001 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00011 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00011 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00011 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00012 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00012 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00012 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00012 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00015 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00015 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00016 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00016 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00017 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00022 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00022 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00023 | - |
at pH 7.4 and 20°C | Escherichia coli | 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | |
0.00026 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00027 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0003 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00031 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(1H-imidazol-1-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00031 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00034 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00035 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00039 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate | |
0.0004 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00041 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00042 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00043 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00046 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00047 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00047 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00049 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(1,3-thiazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0005 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-[4-(hydroxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0005 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00052 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00052 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(thiophen-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00053 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00053 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate | |
0.00055 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00055 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid | |
0.00059 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00062 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)thiophene-2-carboxylic acid | |
0.00064 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(4H-1,2,3-triazol-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00065 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(4-cyanobutyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00067 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00069 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00072 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00072 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(methylsulfanyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00074 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00078 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(3H-pyrazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00079 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-[4-(methoxymethyl)-1,3-thiazol-2-yl]-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00081 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00097 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00101 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0011 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0011 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-propyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00133 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(pyridin-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0014 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(3H-1,2,4-triazol-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00144 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0015 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0016 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00165 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(4,5-dihydro-1,3-oxazol-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0017 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0018 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0018 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(5-cyanopentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0018 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00209 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0021 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00219 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(thiophen-3-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.00224 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 2,4-diamino-7-tert-butyl-4a,8a-dihydro-1,8-naphthyridine-3-carbonitrile | |
0.00275 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(pyridin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0037 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.005 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.0066 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(pyridin-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-(2-methylpropyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-(cyclohexylmethyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-(propan-2-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-benzyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-cyclohexyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-cyclopentyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-cyclopropyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-2-methyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-phenyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-4-carboxylate | |
0.013 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-cyclobutyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.013 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.01398 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(pyrimidin-4-yl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.044 | - |
at pH 7.4 and 20°C | Streptococcus pneumoniae | 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.2 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4-(5-cyclohexylpentyl)-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.2 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-2-tert-butyl-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.2 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | 5,7-diamino-4a,8a-dihydropyrido[2,3-d]pyrimidine-6-carbonitrile | |
0.2 | - |
at pH 7.4 and 20°C | Staphylococcus aureus | ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate | |
0.2 | - |
at pH 7.4 and 20°C | Haemophilus influenzae | ethyl 2-(5,7-diamino-2-tert-butyl-6-cyano-4a,8a-dihydropyrido[2,3-d]pyrimidin-4-yl)-1,3-thiazole-5-carboxylate |