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Literature summary for 6.5.1.1 extracted from

  • Gu, J.; Lu, H.; Tippin, B.; Shimazaki, N.; Goodman, M.F.; Lieber, M.R.
    XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps (2007), EMBO J., 26, 1010-1023.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens XRCC4 and DNA ligase IV form a complex that is essential for the repair of all double-strand DNA breaks by the nonhomologous DNA end joining pathway in eukaryotes AMP + diphosphate + (deoxyribonucleotide)n+m
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m XRCC4 and DNA ligase IV form a complex that is essential for the repair of all double-strand DNA breaks by the nonhomologous DNA end joining pathway in eukaryotes Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
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 ?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m human XRCC4:DNA ligase IV can ligate two double-strand DNA ends that have fully incompatible short 3' overhang configurations with no potential for base pairing. At DNA ends that share 1-4 annealed base pairs, XRCC4:DNA ligase IV can ligate across gaps of 1 nt Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
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 ?

Synonyms

Synonyms Comment Organism
DNA ligase IV
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 Homo sapiens